HCSGD entry for CDH5
1. General information
| Official gene symbol | CDH5 |
|---|---|
| Entrez ID | 1003 |
| Gene full name | cadherin 5, type 2 (vascular endothelium) |
| Other gene symbols | 7B4 CD144 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001955 | Blood vessel maturation | IEA | biological_process |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | IEA TAS | cellular_component |
| GO:0005911 | Cell-cell junction | IDA | cellular_component |
| GO:0005923 | Tight junction | IEA | cellular_component |
| GO:0007156 | Homophilic cell adhesion | IEA | biological_process |
| GO:0008013 | Beta-catenin binding | IPI | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0016020 | Membrane | IEA TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019903 | Protein phosphatase binding | IEA | molecular_function |
| GO:0030054 | Cell junction | ISS | cellular_component |
| GO:0034329 | Cell junction assembly | TAS | biological_process |
| GO:0034332 | Adherens junction organization | TAS | biological_process |
| GO:0044325 | Ion channel binding | IPI | molecular_function |
| GO:0045216 | Cell-cell junction organization | TAS | biological_process |
| GO:0071944 | Cell periphery | IEA | cellular_component |
| GO:2000114 | Regulation of establishment of cell polarity | IEA IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2710487064 | 0.9222645568 | 0.9681466956 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0667838905 |
| GSE13712_SHEAR | Down | -0.0106672722 |
| GSE13712_STATIC | Up | 0.0788182985 |
| GSE19018 | Up | 0.0971785319 |
| GSE19899_A1 | Up | 0.2660500999 |
| GSE19899_A2 | Up | 0.2206903474 |
| PubMed_21979375_A1 | Down | -0.1044626928 |
| PubMed_21979375_A2 | Up | 0.2770705149 |
| GSE35957 | Up | 0.1939518842 |
| GSE36640 | Up | 0.0244442582 |
| GSE54402 | Up | 0.2740113116 |
| GSE9593 | Down | -0.0823399437 |
| GSE43922 | Up | 0.0168412639 |
| GSE24585 | Down | -0.0292721348 |
| GSE37065 | Up | 0.0091999083 |
| GSE28863_A1 | Up | 0.0437747846 |
| GSE28863_A2 | Up | 0.0096621173 |
| GSE28863_A3 | Up | 0.2455089890 |
| GSE28863_A4 | Up | 0.0585280304 |
| GSE48662 | Down | -0.3382428400 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-211-5p | MIMAT0000268 | MIRT006257 | Luciferase reporter assay | Functional MTI | 22235338 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017265 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT021947 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029178 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26413932 | 3% CD144(+) vs |
| 26413932 | 5% CD144(+), P < 0 |
| 24576879 | Western blot analysis showed that the expression level of myosin light chain, claudin-5, and VE-cadherin significantly reduced under pressure elevation in control cells but not in senescent cells |
| 23873025 | Mechanistic studies showed that inducible expression of CD82 in highly metastatic melanoma cells significantly increased p21 expression upon binding of Duffy antigen receptor group (DARC), inducing tumor cell senescence and interrupting IL-8-mediated vascular endothelial (VE)-cadherin disassembly |
| 20424141 | Results of flow cytometry showed that EPCs after 7 days of culture expressed both stem cell markers CD34 and CD133 and endothelial cell markers VEGFR-2 (flk-1) and VE-cadherin |
| 14656709 | After 2 wk of culture with the addition of several growth factors, the CD117(+) stem cells expanded approximately 20-fold and had an endothelial phenotype with high expression of CD34 and vascular endothelial-cadherin |
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