HCSGD entry for TRAP1
1. General information
| Official gene symbol | TRAP1 |
|---|---|
| Entrez ID | 10131 |
| Gene full name | TNF receptor-associated protein 1 |
| Other gene symbols | HSP 75 HSP75 HSP90L TRAP-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005164 | Tumor necrosis factor receptor binding | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IDA | cellular_component |
| GO:0006457 | Protein folding | IEA | biological_process |
| GO:0006950 | Response to stress | IEA | biological_process |
| GO:0051082 | Unfolded protein binding | IEA | molecular_function |
| GO:1901856 | Negative regulation of cellular respiration | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1662939934 | 0.7138283424 | 0.8058584913 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0034499251 |
| GSE13712_SHEAR | Down | -0.0098517074 |
| GSE13712_STATIC | Up | 0.1340556935 |
| GSE19018 | Up | 0.2351512636 |
| GSE19899_A1 | Up | 0.4083664119 |
| GSE19899_A2 | Up | 0.3448235198 |
| PubMed_21979375_A1 | Up | 0.8871012775 |
| PubMed_21979375_A2 | Up | 0.4810559132 |
| GSE35957 | Down | -0.3364227101 |
| GSE36640 | Down | -0.3647175046 |
| GSE54402 | Up | 0.2465859689 |
| GSE9593 | Down | -0.3596641117 |
| GSE43922 | Up | 0.2141874343 |
| GSE24585 | Down | -0.3550465939 |
| GSE37065 | Down | -0.1688913346 |
| GSE28863_A1 | Up | 0.1889522981 |
| GSE28863_A2 | Up | 0.1477902340 |
| GSE28863_A3 | Down | -0.2910237045 |
| GSE28863_A4 | Up | 0.0975624213 |
| GSE48662 | Down | -0.2018278745 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031812 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031812 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1180-3p | MIMAT0005825 | MIRT035913 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-3p | MIMAT0004682 | MIRT038265 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039132 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040106 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041401 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-424-5p | MIMAT0001341 | MIRT042452 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043185 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043532 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-342-3p | MIMAT0000753 | MIRT043734 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045192 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045658 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046825 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048118 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048268 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049372 | CLASH//qRT-PCR | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050189 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050345 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050940 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24382805 | Guardian of the furnace: mitochondria, TRAP1, ROS and stem cell maintenance |
| 24382805 | The mitochondrial molecular chaperone tumor necrosis factor receptor associated protein 1 (TRAP1) is often termed the cytoprotective chaperone for its role in cancer cell survival and protection from apoptosis |
| 24382805 | Here, we hypothesize that TRAP1 serves to modulate mitochondrial activity in stem cell maintenance, survival and differentiation |
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