HCSGD entry for STUB1

1. General information

Official gene symbolSTUB1
Entrez ID10273
Gene full nameSTIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Other gene symbolsCHIP HSPABP2 NY-CO-7 SDCCAG7 UBOX1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000151Ubiquitin ligase complexIDA IEAcellular_component
GO:0000209Protein polyubiquitinationIDA IMPbiological_process
GO:0004842Ubiquitin-protein ligase activityIDA IEA IMP TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006281DNA repairIEAbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0006515Misfolded or incompletely synthesized protein catabolic processIDAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0019900Kinase bindingIPImolecular_function
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0030544Hsp70 protein bindingIDAmolecular_function
GO:0030579Ubiquitin-dependent SMAD protein catabolic processIDAbiological_process
GO:0030674Protein binding, bridgingTASmolecular_function
GO:0030911TPR domain bindingIDAmolecular_function
GO:0031371Ubiquitin conjugating enzyme complexTAScellular_component
GO:0031398Positive regulation of protein ubiquitinationIDAbiological_process
GO:0031625Ubiquitin protein ligase bindingIEAmolecular_function
GO:0031943Regulation of glucocorticoid metabolic processIDAbiological_process
GO:0032436Positive regulation of proteasomal ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0034450Ubiquitin-ubiquitin ligase activityISSmolecular_function
GO:0042405Nuclear inclusion bodyIDAcellular_component
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0046332SMAD bindingIDAmolecular_function
GO:0051604Protein maturationTASbiological_process
GO:0051787Misfolded protein bindingIDAmolecular_function
GO:0051865Protein autoubiquitinationIDAbiological_process
GO:0051879Hsp90 protein bindingIDAmolecular_function
GO:0070534Protein K63-linked ubiquitinationIDAbiological_process
GO:0071218Cellular response to misfolded proteinIDAbiological_process
GO:0090035Positive regulation of chaperone-mediated protein complex assemblyIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01934634320.96360517460.33857386971.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6267565865
GSE13712_SHEARUp0.2295793088
GSE13712_STATICUp0.3018114218
GSE19018Up0.1058508913
GSE19899_A1Up0.4366011300
GSE19899_A2Up0.7967533516
PubMed_21979375_A1Up1.1215348095
PubMed_21979375_A2Up0.7927588032
GSE35957Up0.0002961353
GSE36640Up0.5737361872
GSE54402Up0.4538813774
GSE9593Up0.1642819486
GSE43922Up0.0898396825
GSE24585Down-0.3110113632
GSE37065Down-0.2698242176
GSE28863_A1Down-0.1303045948
GSE28863_A2Down-0.2000601166
GSE28863_A3Up0.1843209239
GSE28863_A4Up0.1325089779
GSE48662Up0.0698319368

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-5pMIMAT0000087MIRT028574ProteomicsFunctional MTI (Weak)18668040
hsa-miR-26b-5pMIMAT0000083MIRT029709MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.