HCSGD entry for LILRB2

1. General information

Official gene symbolLILRB2
Entrez ID10288
Gene full nameleukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
Other gene symbolsCD85D ILT-4 ILT4 LIR-2 LIR2 MIR-10 MIR10
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002578Negative regulation of antigen processing and presentationIDAbiological_process
GO:0002666Positive regulation of T cell tolerance inductionIMPbiological_process
GO:0002767Immune response-inhibiting cell surface receptor signaling pathwayIDA IMPbiological_process
GO:0002774Fc receptor mediated inhibitory signaling pathwayIDAbiological_process
GO:0004872Receptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneICcellular_component
GO:0006955Immune responseTASbiological_process
GO:0006968Cellular defense responseTASbiological_process
GO:0007165Signal transductionIDA IMPbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008157Protein phosphatase 1 bindingIPImolecular_function
GO:0009986Cell surfaceIDAcellular_component
GO:0016020MembraneTAScellular_component
GO:0023029MHC class Ib protein bindingIPImolecular_function
GO:0032396Inhibitory MHC class I receptor activityIDA IMPmolecular_function
GO:0032755Positive regulation of interleukin-6 productionNASbiological_process
GO:0034113Heterotypic cell-cell adhesionIDAbiological_process
GO:0042102Positive regulation of T cell proliferationIDAbiological_process
GO:0042130Negative regulation of T cell proliferationIDA IMPbiological_process
GO:0042288MHC class I protein bindingIDA IPImolecular_function
GO:0045591Positive regulation of regulatory T cell differentiationIMPbiological_process
GO:0050776Regulation of immune responseTASbiological_process
GO:0050839Cell adhesion molecule bindingIPImolecular_function
GO:0051926Negative regulation of calcium ion transportIDAbiological_process
GO:0071222Cellular response to lipopolysaccharideIMPbiological_process
GO:2001198Regulation of dendritic cell differentiationICbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.72050653850.83222184570.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0041558778
GSE13712_SHEARDown-0.1987323739
GSE13712_STATICUp0.0183230293
GSE19018Up0.1323882660
GSE19899_A1Down-0.0270060187
GSE19899_A2Down-0.0100765503
PubMed_21979375_A1Up0.0506603811
PubMed_21979375_A2Up0.0169089929
GSE35957Up0.1231670706
GSE36640Up0.0181789542
GSE54402Up0.0246021080
GSE9593Down-0.1540919949
GSE43922Up0.0810668765
GSE24585Down-0.0079466493
GSE37065Up0.0465793184
GSE28863_A1Down-0.1215851509
GSE28863_A2Down-0.1048184178
GSE28863_A3Up0.3311511554
GSE28863_A4Up0.0930363869
GSE48662Up0.0291586188

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.