HCSGD entry for LANCL1
1. General information
| Official gene symbol | LANCL1 |
|---|---|
| Entrez ID | 10314 |
| Gene full name | LanC lantibiotic synthetase component C-like 1 (bacterial) |
| Other gene symbols | GPR69A p40 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | IDA | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0017124 | SH3 domain binding | IPI | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0043295 | Glutathione binding | IDA | molecular_function |
| GO:0050750 | Low-density lipoprotein particle receptor binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9901900156 | 0.0010723491 | 0.9999902473 | 0.0623075055 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3036835574 |
| GSE13712_SHEAR | Down | -0.3376109366 |
| GSE13712_STATIC | Down | -0.0869435308 |
| GSE19018 | Up | 0.2822187083 |
| GSE19899_A1 | Down | -1.1121910168 |
| GSE19899_A2 | Down | -1.3801281295 |
| PubMed_21979375_A1 | Down | -2.0353146393 |
| PubMed_21979375_A2 | Down | -1.5568005563 |
| GSE35957 | Up | 0.5788083551 |
| GSE36640 | Down | -0.8679106260 |
| GSE54402 | Down | -1.0778050803 |
| GSE9593 | Up | 0.1922143739 |
| GSE43922 | Down | -1.3331936721 |
| GSE24585 | Up | 0.0638116925 |
| GSE37065 | Down | -0.1915977473 |
| GSE28863_A1 | Down | -0.2714638416 |
| GSE28863_A2 | Down | -0.2174480908 |
| GSE28863_A3 | Down | -0.9741120701 |
| GSE28863_A4 | Down | -0.2213397260 |
| GSE48662 | Down | -0.2658273907 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT025923 | Microarray | Functional MTI (Weak) | 19073608 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25412306 | We identified 107 proteins that could be potential markers of senescence and validated 10 of them (DEP1, NTAL, EBP50, STX4, VAMP3, ARMX3, B2MG, LANCL1, VPS26A and PLD3) |
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