HCSGD entry for PEMT
1. General information
| Official gene symbol | PEMT |
|---|---|
| Entrez ID | 10400 |
| Gene full name | phosphatidylethanolamine N-methyltransferase |
| Other gene symbols | PEAMT PEMPT PEMT2 PNMT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000773 | Phosphatidyl-N-methylethanolamine N-methyltransferase activity | IEA | molecular_function |
| GO:0004608 | Phosphatidylethanolamine N-methyltransferase activity | IEA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006629 | Lipid metabolic process | TAS | biological_process |
| GO:0006644 | Phospholipid metabolic process | IEA TAS | biological_process |
| GO:0006656 | Phosphatidylcholine biosynthetic process | IEA TAS | biological_process |
| GO:0008170 | N-methyltransferase activity | IEA | molecular_function |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0031966 | Mitochondrial membrane | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
| GO:0080101 | Phosphatidyl-N-dimethylethanolamine N-methyltransferase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9721344668 | 0.0108438813 | 0.9999902473 | 0.2064739568 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0687836319 |
| GSE13712_SHEAR | Down | -0.0357850196 |
| GSE13712_STATIC | Down | -0.2315792688 |
| GSE19018 | Up | 0.0385428852 |
| GSE19899_A1 | Down | -0.7641097409 |
| GSE19899_A2 | Down | -1.6365359205 |
| PubMed_21979375_A1 | Up | 0.3822385019 |
| PubMed_21979375_A2 | Down | -1.3307353790 |
| GSE35957 | Down | -0.5269267513 |
| GSE36640 | Down | -0.0001423806 |
| GSE54402 | Down | -0.0518092850 |
| GSE9593 | Down | -0.1174116879 |
| GSE43922 | Down | -0.8852129213 |
| GSE24585 | Down | -0.7497342774 |
| GSE37065 | Down | -0.0702204799 |
| GSE28863_A1 | Down | -0.2389137883 |
| GSE28863_A2 | Down | -0.3389205925 |
| GSE28863_A3 | Up | 0.0930733472 |
| GSE28863_A4 | Up | 0.0721535682 |
| GSE48662 | Up | 0.0341990047 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022625 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
