HCSGD entry for TACC3
1. General information
| Official gene symbol | TACC3 |
|---|---|
| Entrez ID | 10460 |
| Gene full name | transforming, acidic coiled-coil containing protein 3 |
| Other gene symbols | ERIC-1 ERIC1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005813 | Centrosome | IDA IEA | cellular_component |
| GO:0019904 | Protein domain specific binding | IEA | molecular_function |
| GO:0021987 | Cerebral cortex development | IEA | biological_process |
| GO:0022008 | Neurogenesis | IEA | biological_process |
| GO:0022027 | Interkinetic nuclear migration | IEA | biological_process |
| GO:0030097 | Hemopoiesis | IEA | biological_process |
| GO:0030953 | Astral microtubule organization | IEA | biological_process |
| GO:0032886 | Regulation of microtubule-based process | IEA | biological_process |
| GO:0042994 | Cytoplasmic sequestering of transcription factor | IEA | biological_process |
| GO:0051726 | Regulation of cell cycle | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9936816078 | 0.0000501577 | 0.9999902473 | 0.0114800000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5950179787 |
| GSE13712_SHEAR | Down | -0.3099705767 |
| GSE13712_STATIC | Down | -0.4714240881 |
| GSE19018 | Up | 0.0927044241 |
| GSE19899_A1 | Down | -1.0308651867 |
| GSE19899_A2 | Down | -4.1129529359 |
| PubMed_21979375_A1 | Down | -2.3616539083 |
| PubMed_21979375_A2 | Down | -3.7590143954 |
| GSE35957 | Down | -2.8685800878 |
| GSE36640 | Down | -4.1666087557 |
| GSE54402 | Down | -0.9509343874 |
| GSE9593 | Down | -1.9484689260 |
| GSE43922 | Down | -0.7630167151 |
| GSE24585 | Down | -0.1977093106 |
| GSE37065 | Down | -0.5536159181 |
| GSE28863_A1 | Down | -0.1524698161 |
| GSE28863_A2 | Up | 0.1580563755 |
| GSE28863_A3 | Up | 0.1417737841 |
| GSE28863_A4 | Up | 0.0392878445 |
| GSE48662 | Down | -1.4770284969 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016566 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016566 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037681 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039103 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040904 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042910 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043259 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045607 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20729911 | The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program |
| 20729911 | Unlike PTX, knockdown of TACC3 did not trigger a cell death response, but instead resulted in a progressive loss of the pro-apoptotic Bcl-2 protein Bim that links microtubule integrity to spindle poison-induced cell death |
| 20729911 | Remarkably, the onset of senescence following TACC3 knockdown was strongly accelerated in the presence of non-toxic PTX concentrations |
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