HCSGD entry for CEBPB
1. General information
| Official gene symbol | CEBPB |
|---|---|
| Entrez ID | 1051 |
| Gene full name | CCAAT/enhancer binding protein (C/EBP), beta |
| Other gene symbols | C/EBP-beta CRP2 IL6DBP LAP NF-IL6 TCF5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000790 | Nuclear chromatin | IEA | cellular_component |
| GO:0001077 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | IEA | molecular_function |
| GO:0001892 | Embryonic placenta development | IEA | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | NAS | molecular_function |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006953 | Acute-phase response | TAS | biological_process |
| GO:0006954 | Inflammatory response | TAS | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0008134 | Transcription factor binding | IEA | molecular_function |
| GO:0016363 | Nuclear matrix | IEA | cellular_component |
| GO:0030182 | Neuron differentiation | IEA | biological_process |
| GO:0032496 | Response to lipopolysaccharide | IEA | biological_process |
| GO:0033598 | Mammary gland epithelial cell proliferation | IEA | biological_process |
| GO:0034976 | Response to endoplasmic reticulum stress | IDA | biological_process |
| GO:0035259 | Glucocorticoid receptor binding | IEA | molecular_function |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045408 | Regulation of interleukin-6 biosynthetic process | IEA | biological_process |
| GO:0045669 | Positive regulation of osteoblast differentiation | IEA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0050873 | Brown fat cell differentiation | IEA | biological_process |
| GO:0060644 | Mammary gland epithelial cell differentiation | IEA | biological_process |
| GO:0071230 | Cellular response to amino acid stimulus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0021812165 | 0.9983118043 | 0.1256275711 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2789781270 |
| GSE13712_SHEAR | Up | 0.5830376644 |
| GSE13712_STATIC | Up | 0.3745837828 |
| GSE19018 | Up | 0.3826567452 |
| GSE19899_A1 | Up | 0.4608945305 |
| GSE19899_A2 | Up | 0.9662923443 |
| PubMed_21979375_A1 | Up | 1.7202750490 |
| PubMed_21979375_A2 | Up | 1.2131302839 |
| GSE35957 | Up | 0.3419599491 |
| GSE36640 | Up | 0.4660001311 |
| GSE54402 | Up | 0.5618408826 |
| GSE9593 | Up | 0.2122495530 |
| GSE43922 | Up | 0.6814782470 |
| GSE24585 | Up | 0.0450939025 |
| GSE37065 | Up | 0.2371944599 |
| GSE28863_A1 | Up | 0.0094323943 |
| GSE28863_A2 | Up | 0.4357467840 |
| GSE28863_A3 | Up | 0.1842551332 |
| GSE28863_A4 | Down | -0.0622873515 |
| GSE48662 | Up | 0.4877489081 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT001560 | Luciferase reporter assay | Functional MTI | 18367535 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT001560 | Microarray//qRT-PCR//Western blot | Functional MTI | 19193853 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT001560 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20427544 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT001560 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT001560 | Luciferase reporter assay | Functional MTI | 19596814 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT001560 | ELISA//Immunoblot//Immunocytochemistry//Immunofluorescence//Luciferase reporter assay//qRT-PCR | Functional MTI | 19887047 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT005723 | Luciferase reporter assay//Reporter assay | Non-Functional MTI | 20598588 |
| hsa-miR-421 | MIMAT0003339 | MIRT016122 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038165 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | 1 | hsa-miR-155 | {Western blot} | {overexpression by miRNA mimics tranfection} | 19887047 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 13 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25772238 | CCAAT/Enhancer Binding Protein (C/EBP) beta function is frequently deregulated in human malignancies and interestingly, androgen-sensitive PC cells express primarily the liver-enriched inhibitory protein isoform |
| 25772238 | We found that C/EBPbeta expression is negatively regulated by androgen receptor (AR) activity and that treatment of androgen-sensitive cell lines with anti-androgens increases C/EBPbeta mRNA and protein levels |
| 25772238 | Accordingly, we also find that C/EBPbeta levels are significantly elevated in primary PC samples from castration-resistant compared with therapy-naive patients |
| 25772238 | Chromatin immunoprecipitation demonstrated enhanced binding of the AR to the proximal promoter of the CEBPB gene in the presence of dihydroxytestosterone |
| 25772238 | Upon androgen deprivation, induction of C/EBPbeta is facilitated by active transcription as evident by increased histone 3 acetylation at the C/EBPbeta promoter |
| 25772238 | Also, the androgen agonist R1881 suppresses the activity of a CEBPB promoter reporter |
| 25772238 | Loss of C/EBPbeta expression prevents growth arrest following androgen deprivation or anti-androgen challenge |
| 25772238 | Accordingly, suppression of C/EBPbeta under low androgen conditions results in reduced expression of senescence-associated secretory genes, significantly decreased number of cells displaying heterochromatin foci and increased numbers of Ki67-positive cells |
| 25772238 | Ectopic expression of C/EBPbeta caused pronounced morphological changes, reduced PC cell growth and increased the number of senescent LNCaP cells |
| 25772238 | Our data demonstrate that upregulation of C/EBPbeta is critical for complete maintenance of androgen deprivation-induced senescence and that targeting C/EBPbeta expression may synergize with anti-androgen or chemotherapy in eradicating PC |
| 25482089 | Compared with normal pituitary cells, the aging pituitary tissues revealed increased expression of IL6, C/EBPbeta, p53, p21 and p16 and decreased expression of pituitary tumor transforming gene |
| 25472717 | This upregulates the downstream proteins CEBPB, FAK, N-cadherin, vimentin, Oct4 and Sca-1 (also known as stem cell antigen-1), and downregulates E-cadherin |
| 25248477 | Transcription of the Id genes is controlled by transcription factors such as C/EBPbeta and Egr as well as by signaling pathways triggered by different stimuli, which include bone morphogenic proteins, cytokines, and ligands of T cell receptors |
| 23775115 | C/EBPgamma suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBPbeta |
| 23775115 | C/EBPbeta is an important regulator of oncogene-induced senescence (OIS) |
| 23775115 | Here, we show that C/EBPgamma, a heterodimeric partner of C/EBPbeta whose biological functions are not well understood, inhibits cellular senescence |
| 23775115 | Cebpg(-/-) mouse embryonic fibroblasts (MEFs) proliferated poorly, entered senescence prematurely, and expressed a proinflammatory gene signature, including elevated levels of senescence-associated secretory phenotype (SASP) genes whose induction by oncogenic stress requires C/EBPbeta |
| 23775115 | The senescence-suppressing activity of C/EBPgamma required its ability to heterodimerize with C/EBPbeta |
| 23775115 | C/EBPbeta depletion partially restored growth of C/EBPgamma-deficient cells, indicating that the increased levels of C/EBPbeta homodimers in Cebpg(-/-) MEFs inhibit proliferation |
| 23775115 | Our findings demonstrate that C/EBPgamma neutralizes the cytostatic activity of C/EBPbeta through heterodimerization, which prevents senescence and suppresses basal transcription of SASP genes |
| 21448135 | This was accompanied by the suppression of several inflammatory factors and p15(INK4B), with TSC22D1 acting as a critical effector of C/EBPbeta |
| 21353395 | Senescence of chondrocytes in aging articular cartilage: GADD45beta mediates p21 expression in association with C/EBPbeta in senescence-accelerated mice |
| 21353395 | We recently reported that GADD45beta enhances CCAAT/enhancer binding protein beta (C/EBPbeta) activation in vitro |
| 21353395 | This study was undertaken in order to determine whether GADD45beta is expressed with C/EBPbeta in aging articular cartilage |
| 21353395 | We also investigated whether the synergistic expression of GADD45beta and C/EBPbeta may be involved in the mechanism of chondrocyte senescence |
| 21353395 | GADD45beta, C/EBPbeta, and p21 were analyzed by immunohistochemistry |
| 21353395 | The co-localization of GADD45beta and C/EBPbeta was confirmed by double immunostaining |
| 21353395 | The synergistic mechanisms of GADD45beta and C/EBPbeta on the gene regulation of p21, a molecule related to cellular senescence, were verified by a p21-luciferase reporter assay |
| 21353395 | Co-expression of C/EBPbeta and p21 was confirmed |
| 21353395 | These observations suggest that the synergism between GADD45beta and C/EBPbeta may play an important role in cellular senescence in the aging articular cartilage |
| 20446924 | It was previously reported that binding of two transcription factors, C/EBPbeta and RBP-Jkappa, to a regulatory site on the p53 promoter regulates its activity, in vitro, in a cell cycle-dependent manner |
| 20446924 | C/EBPbeta is a CCAAT enhancer-binding protein that is a member of the basic leucine zipper transcription factor (bZIP) family that plays an important role in mediating cell proliferation, differentiation and can also be involved in inflammatory responses, metabolism, cellular transformation, oncogene-induced senescence and tumorigenesis |
| 20446924 | Our reports, here and previously published, show that repression of p53 by RBP-Jkappa and activation of p53 by C/EBPbeta through differential binding of these two factors indicates a type of co-operative regulation in p53 expression |
| 19805069 | Furthermore, IL-1alpha depletion reduced the DNA binding activity of NF-kappaB and C/EBPbeta, which stimulate IL-6/IL-8 transcription |
| 18555778 | Furthermore, we demonstrate that the transcription factor C/EBPbeta cooperates with IL-6 to amplify the activation of the inflammatory network, including IL-8 |
| 18555777 | Cells undergoing OIS secrete multiple CXCR2-binding chemokines in a program that is regulated by the NF-kappaB and C/EBPbeta transcription factors and coordinately induce CXCR2 expression |
| 16687924 | Stop and go: anti-proliferative and mitogenic functions of the transcription factor C/EBPbeta |
| 16687924 | We recently discovered that the bZIP transcription factor C/EBPbeta, a downstream target of Ras signaling, is an essential component of RasV12-mediated senescence in mouse embryo fibroblasts (MEFs) |
| 16687924 | Although C/EBPbeta has tumor suppressor-like activity in MEFs, other observations point to critical pro-oncogenic functions for C/EBPbeta in certain cancers |
| 16687924 | Here we review the evidence for positive and negative cell cycle regulation by C/EBPbeta and discuss possible mechanisms by which this transcription factor could participate in both cellular senescence and oncogenic transformation |
| 16107878 | C/EBPbeta cooperates with RB:E2F to implement Ras(V12)-induced cellular senescence |
| 16107878 | Here we show that the transcription factor C/EBPbeta is required for Ras(V12)-induced senescence |
| 16107878 | C/EBPbeta-/- mouse embryo fibroblasts (MEFs) expressing Ras(V12) continued to proliferate despite unimpaired induction of p19ARF and p53, and lacked morphological features of senescent fibroblasts |
| 16107878 | Enforced C/EBPbeta expression inhibited proliferation of wild-type MEFs and also slowed proliferation of p19Arf-/- and p53-/- cells, indicating that C/EBPbeta acts downstream or independently of p19ARF/p53 to suppress growth |
| 16107878 | C/EBPbeta was unable to inhibit proliferation of MEFs lacking all three RB family proteins or wild-type cells expressing dominant negative E2F-1 and, instead, stimulated their growth |
| 16107878 | C/EBPbeta decreased expression of several E2F target genes and was associated with their promoters in chromatin immunoprecipitation assays, suggesting that C/EBPbeta functions by repressing genes required for cell cycle progression |
| 16107878 | C/EBPbeta is therefore a novel component of the RB:E2F-dependent senescence program activated by oncogenic stress in primary cells |
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