HCSGD entry for FBLN5


1. General information

Official gene symbolFBLN5
Entrez ID10516
Gene full namefibulin 5
Other gene symbolsADCL2 ARCL1A ARMD3 DANCE EVEC FIBL-5 UP50
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001558Regulation of cell growthIEAbiological_process
GO:0004888Transmembrane signaling receptor activityIEAmolecular_function
GO:0005178Integrin bindingTASmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005578Proteinaceous extracellular matrixTAScellular_component
GO:0005615Extracellular spaceIDA IEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0007160Cell-matrix adhesionTASbiological_process
GO:0007596Blood coagulationIEAbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0016020MembraneIEAcellular_component
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0031012Extracellular matrixIDAcellular_component
GO:0034394Protein localization to cell surfaceIEA ISSbiological_process
GO:0048251Elastic fiber assemblyIEA ISSbiological_process
GO:0071953Elastic fiberIEA ISScellular_component
GO:2000121Regulation of removal of superoxide radicalsIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31049554350.00088791840.99999024730.0566338902

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1551479949
GSE13712_SHEARDown-2.1876944626
GSE13712_STATICDown-2.1301549885
GSE19018Down-0.7484634664
GSE19899_A1Down-2.1006236717
GSE19899_A2Down-1.6775744714
PubMed_21979375_A1Down-1.8619389935
PubMed_21979375_A2Down-1.7701408577
GSE35957Up1.4258330225
GSE36640Up0.4728065502
GSE54402Down-1.6168499804
GSE9593Up0.6368366765
GSE43922Down-0.2039701863
GSE24585Up0.5194282968
GSE37065Up0.3572229824
GSE28863_A1Down-0.0048917084
GSE28863_A2Down-0.4926856230
GSE28863_A3Up0.0312892372
GSE28863_A4Down-0.1289697792
GSE48662Up0.5600803156

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-200c-3pMIMAT0000617MIRT006770Luciferase reporter assay//Western blotFunctional MTI22569286
hsa-miR-335-5pMIMAT0000765MIRT018518MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT029864MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20816692Finally, given the importance of the elastic component for a long-lasting connective tissue structural and functional compliance, this study focuses also on elastin and fibulin-5 synthesis and deposition, demonstrating a close relationship between fibulin-5 and ageing
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