HCSGD entry for CLPX
1. General information
| Official gene symbol | CLPX |
|---|---|
| Entrez ID | 10845 |
| Gene full name | ClpX caseinolytic peptidase X homolog (E. coli) |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004176 | ATP-dependent peptidase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA ISS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA NAS | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA ISS | cellular_component |
| GO:0006457 | Protein folding | IEA | biological_process |
| GO:0009841 | Mitochondrial endopeptidase Clp complex | IDA | cellular_component |
| GO:0010952 | Positive regulation of peptidase activity | IDA | biological_process |
| GO:0016504 | Peptidase activator activity | IDA | molecular_function |
| GO:0016887 | ATPase activity | IEA ISS | molecular_function |
| GO:0042645 | Mitochondrial nucleoid | IDA | cellular_component |
| GO:0043085 | Positive regulation of catalytic activity | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050790 | Regulation of catalytic activity | IDA | biological_process |
| GO:0051082 | Unfolded protein binding | IEA | molecular_function |
| GO:0051603 | Proteolysis involved in cellular protein catabolic process | IDA | biological_process |
| GO:0052547 | Regulation of peptidase activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0577142738 | 0.9241841115 | 0.5208685293 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0213997105 |
| GSE13712_SHEAR | Down | -0.0326727383 |
| GSE13712_STATIC | Up | 0.0237746705 |
| GSE19018 | Up | 0.2559440408 |
| GSE19899_A1 | Up | 0.6921051331 |
| GSE19899_A2 | Up | 0.6156558972 |
| PubMed_21979375_A1 | Up | 0.4288060186 |
| PubMed_21979375_A2 | Up | 0.4482279968 |
| GSE35957 | Up | 0.0624716221 |
| GSE36640 | Up | 0.0848152036 |
| GSE54402 | Up | 0.0629080388 |
| GSE9593 | Down | -0.4107765067 |
| GSE43922 | Up | 0.1069313655 |
| GSE24585 | Up | 0.0325703626 |
| GSE37065 | Down | -0.1373379446 |
| GSE28863_A1 | Up | 0.6079578259 |
| GSE28863_A2 | Up | 0.3421769578 |
| GSE28863_A3 | Up | 0.0057594043 |
| GSE28863_A4 | Up | 0.1514034508 |
| GSE48662 | Down | -0.2737725160 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT032371 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
