HCSGD entry for LILRB1

1. General information

Official gene symbolLILRB1
Entrez ID10859
Gene full nameleukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
Other gene symbolsCD85J ILT-2 ILT2 LIR-1 LIR1 MIR-7 MIR7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001915Negative regulation of T cell mediated cytotoxicityIDAbiological_process
GO:0002230Positive regulation of defense response to virus by hostIDAbiological_process
GO:0002309T cell proliferation involved in immune responseIDAbiological_process
GO:0002740Negative regulation of cytokine secretion involved in immune responseIDAbiological_process
GO:0002767Immune response-inhibiting cell surface receptor signaling pathwayNASbiological_process
GO:0002774Fc receptor mediated inhibitory signaling pathwayIDAbiological_process
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007165Signal transductionIDAbiological_process
GO:0008157Protein phosphatase 1 bindingIPImolecular_function
GO:0009615Response to virusIDAbiological_process
GO:0009897External side of plasma membraneIDAcellular_component
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0014063Negative regulation of serotonin secretionIDAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0030107HLA-A specific inhibitory MHC class I receptor activityIDAmolecular_function
GO:0030109HLA-B specific inhibitory MHC class I receptor activityIDAmolecular_function
GO:0031623Receptor internalizationTASbiological_process
GO:0032393MHC class I receptor activityIDAmolecular_function
GO:0032609Interferon-gamma productionIDAbiological_process
GO:0032689Negative regulation of interferon-gamma productionIDAbiological_process
GO:0032945Negative regulation of mononuclear cell proliferationIDAbiological_process
GO:0035548Negative regulation of interferon-beta secretionIDAbiological_process
GO:0042130Negative regulation of T cell proliferationIDAbiological_process
GO:0042169SH2 domain bindingIDAmolecular_function
GO:0042288MHC class I protein bindingIDA IMP IPImolecular_function
GO:0042536Negative regulation of tumor necrosis factor biosynthetic processIDAbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0045077Negative regulation of interferon-gamma biosynthetic processIDAbiological_process
GO:0045786Negative regulation of cell cycleIDAbiological_process
GO:0045806Negative regulation of endocytosisIDAbiological_process
GO:0045919Positive regulation of cytolysisIDA IMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterNASbiological_process
GO:0045953Negative regulation of natural killer cell mediated cytotoxicityIDAbiological_process
GO:0046636Negative regulation of alpha-beta T cell activationIDAbiological_process
GO:0050776Regulation of immune responseTASbiological_process
GO:0051607Defense response to virusIDAbiological_process
GO:0051926Negative regulation of calcium ion transportIDAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEPbiological_process
GO:0072643Interferon-gamma secretionIDAbiological_process
GO:0097028Dendritic cell differentiationIEPbiological_process
GO:2000669Negative regulation of dendritic cell apoptotic processIDAbiological_process
GO:2001180Negative regulation of interleukin-10 secretionIDAbiological_process
GO:2001183Negative regulation of interleukin-12 secretionIDAbiological_process
GO:2001186Negative regulation of CD8-positive, alpha-beta T cell activationIDAbiological_process
GO:2001189Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellIDAbiological_process
GO:2001193Positive regulation of gamma-delta T cell activation involved in immune responseIDAbiological_process
GO:2001199Negative regulation of dendritic cell differentiationIMPbiological_process
GO:2001202Negative regulation of transforming growth factor-beta secretionIDAbiological_process
GO:2001205Negative regulation of osteoclast developmentIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.85665097450.82837864060.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0241675789
GSE13712_SHEARDown-0.1475550179
GSE13712_STATICDown-0.0071508389
GSE19018Up0.1260439483
GSE19899_A1Up0.0615740633
GSE19899_A2Up0.0722020475
PubMed_21979375_A1Down-0.0896145779
PubMed_21979375_A2Down-0.0054709882
GSE35957Up0.0839480736
GSE36640Up0.0423787479
GSE54402Up0.0226226922
GSE9593Up0.0011886764
GSE43922Down-0.0427409077
GSE24585Up0.0766546217
GSE37065Down-0.0193539535
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.0744958682

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.