HCSGD entry for EHMT2
1. General information
| Official gene symbol | EHMT2 |
|---|---|
| Entrez ID | 10919 |
| Gene full name | euchromatic histone-lysine N-methyltransferase 2 |
| Other gene symbols | BAT8 C6orf30 G9A GAT8 KMT1C NG36 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0002039 | P53 binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA ISS | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0006275 | Regulation of DNA replication | IMP | biological_process |
| GO:0006306 | DNA methylation | ISS | biological_process |
| GO:0007130 | Synaptonemal complex assembly | IEA | biological_process |
| GO:0007286 | Spermatid development | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0009566 | Fertilization | IEA | biological_process |
| GO:0010424 | DNA methylation on cytosine within a CG sequence | IEA | biological_process |
| GO:0016279 | Protein-lysine N-methyltransferase activity | IDA | molecular_function |
| GO:0016571 | Histone methylation | IMP | biological_process |
| GO:0018024 | Histone-lysine N-methyltransferase activity | IEA IMP | molecular_function |
| GO:0018027 | Peptidyl-lysine dimethylation | IDA | biological_process |
| GO:0035265 | Organ growth | IEA | biological_process |
| GO:0046974 | Histone methyltransferase activity (H3-K9 specific) | ISS | molecular_function |
| GO:0046976 | Histone methyltransferase activity (H3-K27 specific) | ISS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6830691539 | 0.3819409939 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0493678519 |
| GSE13712_SHEAR | Down | -0.2280414122 |
| GSE13712_STATIC | Down | -0.0186385933 |
| GSE19018 | Up | 0.0286467624 |
| GSE19899_A1 | Down | -0.1465049513 |
| GSE19899_A2 | Down | -0.1121100080 |
| PubMed_21979375_A1 | Up | 0.0705826098 |
| PubMed_21979375_A2 | Up | 0.2136342057 |
| GSE35957 | Up | 0.0614846098 |
| GSE36640 | Down | -0.1894364832 |
| GSE54402 | Down | -0.0580939445 |
| GSE9593 | Up | 0.0455357662 |
| GSE43922 | Down | -0.5812765645 |
| GSE24585 | Down | -0.3827298121 |
| GSE37065 | Down | -0.1047237032 |
| GSE28863_A1 | Up | 0.3529341424 |
| GSE28863_A2 | Up | 0.5546894591 |
| GSE28863_A3 | Down | -0.0268400747 |
| GSE28863_A4 | Down | -0.0197925898 |
| GSE48662 | Up | 0.3448562450 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001368 | pSILAC//Proteomics;Other//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-320b | MIMAT0005792 | MIRT036236 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040361 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046189 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT051011 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22536950 | G9a (also named euchromatin histone methyltransferase 2 (EHMT2)) catalyzes methylation of lysine 9 on histone H3 (H3K9), a modification linked to aberrant silencing of tumor-suppressor genes, among others |
| 22536950 | ATM-pathway activation, caused by either genetic or small-molecule inhibition of G9a, may mediate BRD4770-induced cell senescence |
| 22536950 | BRD4770 may be a useful tool to study G9a and its role in senescence and cancer cell biology |
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