| 20600782 | Human MORF4 encodes a related but truncated protein that is capable of promoting cellular senescence in a subset of human tumor cell lines |
| 20600782 | A truncated form of DmMRG15 (called DmMT1) was designed to mimic the structure of human MORF4, and expression of this mutant protein or the inverted-repeat constructs inhibited fertility in females |
| 20536842 | In our studies to identify senescence-related genes, we cloned Morf4, which induced senescence in a subset of tumor cells |
| 20536842 | In contrast to MORF4, MRG15 and MRGX are positive regulators of cell division |
| 19769966 | The cell senescence inducing gene product MORF4 is regulated by degradation via the ubiquitin/proteasome pathway |
| 19769966 | To facilitate analyses of this gene, which is toxic to cells at low levels, we obtained stable clones of HeLa cells expressing a tetracycline-induced MORF4 construct that could be induced by doxycycline in a dose-dependent manner |
| 19769966 | MORF4 induction resulted in reduced colony formation after 14 days of culture, as previously observed |
| 19769966 | We determined that MORF4 protein was unstable and that addition of the proteasome inhibitor MG132 resulted in the accumulation of the protein |
| 19769966 | It is therefore possible that MORF4 protein, which escapes degradation in the cytoplasm, is transported to the nucleus where it is functional |
| 17460191 | Study of one of these genetic complementation groups demonstrated that one gene, MORF4, possessed the ability to induce senescence in group B cell lines |
| 17460191 | The MRG family of genes, of which MORF4 is a member, has since proven important for cellular aging, proliferation, positive and negative transcriptional regulation, and DNA damage repair |
| 12391155 | Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split |
| 12391155 | This family comprises MORF on chromosome 4 (MORF4) and MORF-related genes on chromosomes X and 15 (MRGX and MRG15, respectively) and is proposed to contribute to cellular senescence |
| 12391155 | While the MORFs may have common functions, MRG15, but not MRGX or MORF4, interacted with Pf1 |
| 12391155 | Therefore, MRG15 may have functions that are distinct from those of MRGX and MORF4 |
| 12391155 | Consistent with this hypothesis, Pf1 reduced transcriptional repression by Gal4-MRG15 but it had no effect on repression by MRGX and MORF4 |
| 12044941 | MORF4 was cloned as the senescence-related gene on human chromosome 4 and is a member of a new gene family, which has multiple transcription factor-like motifs |
| 11280020 | We have now cloned the gene on chromosome 4, MORF4 (mortality factor on chromosome 4) |
| 11280020 | It is a member of a family of seven genes and only MORF4 and the MORF-related genes MRG15 and MRGX are expressed |
| 9891081 | We report the cloning and identification of a gene, mortality factor 4 (MORF 4), which induces a senescent-like phenotype in immortal cell lines assigned to complementation group B with concomitant changes in two markers for senescence |
