HCSGD entry for METAP2
1. General information
| Official gene symbol | METAP2 |
|---|---|
| Entrez ID | 10988 |
| Gene full name | methionyl aminopeptidase 2 |
| Other gene symbols | MAP2 MNPEP p67 p67eIF2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004177 | Aminopeptidase activity | IDA IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007603 | Phototransduction, visible light | TAS | biological_process |
| GO:0008235 | Metalloexopeptidase activity | IDA IEA | molecular_function |
| GO:0016056 | Rhodopsin mediated signaling pathway | TAS | biological_process |
| GO:0016485 | Protein processing | IDA | biological_process |
| GO:0018206 | Peptidyl-methionine modification | IDA | biological_process |
| GO:0022400 | Regulation of rhodopsin mediated signaling pathway | TAS | biological_process |
| GO:0031365 | N-terminal protein amino acid modification | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0070006 | Metalloaminopeptidase activity | IEA | molecular_function |
| GO:0070084 | Protein initiator methionine removal | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5086920292 | 0.2891971620 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0625947229 |
| GSE13712_SHEAR | Down | -0.2517434930 |
| GSE13712_STATIC | Up | 0.0215366511 |
| GSE19018 | Down | -0.5013298828 |
| GSE19899_A1 | Up | 0.3715011774 |
| GSE19899_A2 | Up | 0.1798142991 |
| PubMed_21979375_A1 | Up | 0.2472010956 |
| PubMed_21979375_A2 | Up | 0.3454699304 |
| GSE35957 | Down | -0.0021939262 |
| GSE36640 | Down | -0.2119222267 |
| GSE54402 | Up | 0.1161431563 |
| GSE9593 | Down | -0.4462077651 |
| GSE43922 | Up | 0.1548551864 |
| GSE24585 | Down | -0.1030751769 |
| GSE37065 | Down | -0.2007216170 |
| GSE28863_A1 | Up | 0.0749824237 |
| GSE28863_A2 | Down | -0.1196015704 |
| GSE28863_A3 | Down | -0.4190910023 |
| GSE28863_A4 | Up | 0.3597554845 |
| GSE48662 | Down | -0.2939072572 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Nitroxoline | DB01422 | - |
| 3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium | DB02310 | EXPT03080 |
| Fumagillin | DB02640 | EXPT01509 |
| D-Methionine | DB02893 | EXPT02150 |
| N'-(2s,3r)-3-Amino-4-Cyclohexyl-2-Hydroxy-Butano-N-(4-Methylphenyl)Hydrazide | DB03086 | EXPT00527 |
| (E)-(2r,3r,4s,5r)-3,4,5-Trihydroxy-2-Methoxy-8,8-Dimethyl-Non-6-Enoic Acid ((3s,6r)-6-Hydroxy-2-Oxo-Azepan-3-Yl)-Amide | DB03396 | EXPT03029 |
| 2-Methyl-2-Propanol | DB03900 | EXPT03021 |
| (2s,3r)-3-Amino-2-Hydroxy-5-(Ethylsulfanyl)Pentanoyl-((S)-(-)-(1-Naphthyl)Ethyl)Amide | DB04108 | EXPT00526 |
| Ovalicin | DB04324 | EXPT02454 |
| PPI-2458 | DB05864 | - |
| 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID | DB07309 | - |
| 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID | DB07313 | - |
| 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID | DB07322 | - |
| 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID | DB07323 | - |
| N'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE | DB07377 | - |
| 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID | DB07746 | - |
| (CHLOROACETYL)CARBAMIC ACID (3R,4S,5S,5R)-5-METHOXY-4-[(2R,3R)-2-METHYL-3-(3-METHYL-2-BUTENYL)OXIRANYL]-1-OXASPIRO[2.5]OCT-6-YL ESTER | DB08633 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020542 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022163 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030371 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031408 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051737 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
