HCSGD entry for RAPGEF4
1. General information
| Official gene symbol | RAPGEF4 |
|---|---|
| Entrez ID | 11069 |
| Gene full name | Rap guanine nucleotide exchange factor (GEF) 4 |
| Other gene symbols | CAMP-GEFII CGEF2 EPAC2 Nbla00496 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005085 | Guanyl-nucleotide exchange factor activity | IEA TAS | molecular_function |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005952 | CAMP-dependent protein kinase complex | IEA | cellular_component |
| GO:0006112 | Energy reserve metabolic process | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008603 | CAMP-dependent protein kinase regulator activity | IEA | molecular_function |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0017016 | Ras GTPase binding | IEA ISS | molecular_function |
| GO:0017156 | Calcium ion-dependent exocytosis | IEA | biological_process |
| GO:0017157 | Regulation of exocytosis | IEA | biological_process |
| GO:0019933 | CAMP-mediated signaling | IEA | biological_process |
| GO:0030073 | Insulin secretion | IEA | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030552 | CAMP binding | IEA ISS | molecular_function |
| GO:0032318 | Regulation of Ras GTPase activity | ISS | biological_process |
| GO:0043087 | Regulation of GTPase activity | ISS TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050796 | Regulation of insulin secretion | TAS | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0321738194 | 0.6597486494 | 0.4142465071 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5745702997 |
| GSE13712_SHEAR | Down | -1.9628317137 |
| GSE13712_STATIC | Down | -0.4013865035 |
| GSE19018 | Up | 0.4222359920 |
| GSE19899_A1 | Up | 0.1710341753 |
| GSE19899_A2 | Up | 0.4687493591 |
| PubMed_21979375_A1 | Up | 1.6996338490 |
| PubMed_21979375_A2 | Up | 0.8955141777 |
| GSE35957 | Up | 0.1623694650 |
| GSE36640 | Down | -0.5679864184 |
| GSE54402 | Up | 0.9669284054 |
| GSE9593 | Up | 0.1721633677 |
| GSE43922 | Down | -0.1430065297 |
| GSE24585 | Down | -0.0412479369 |
| GSE37065 | Up | 0.2645357150 |
| GSE28863_A1 | Up | 0.0356856626 |
| GSE28863_A2 | Up | 0.2798664642 |
| GSE28863_A3 | Up | 0.0323918925 |
| GSE28863_A4 | Up | 0.0209046680 |
| GSE48662 | Down | -0.0764487187 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018141 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027613 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029706 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25378661 | We have previously reported that exchange protein directly activated by cAMP 2 (EPAC2, RAPGEF4), another cAMP mediator, is involved in the differentiation of endometrial stromal cells through the regulation of the expression of calreticulin (CALR) |
| 25378661 | EPAC2 knockdown suppressed the expression of CALR protein and mRNA in EM1 cells |
| 25378661 | In addition, knockdown of EPAC2 or CALR increased senescence-associated beta galactosidase activity and expression of p21 but decreased expression of p53 |
| 25378661 | These findings indicate that expression of CALR regulated by EPAC2 in endometrial glandular epithelial cells is critical for the expression of LIF and PTGS2-mediated production of PGE2 through cAMP signaling |
| 25378661 | Furthermore, EPAC2 and CALR could play a role in the maintenance of gland function |
| 24169561 | The present study was undertaken to identify additional downstream targets of EPAC2 associated with decidualization |
| 24169561 | Furthermore, CRT knock-down suppressed the ovarian steroid-stimulated PRL and IGFBP1 expression and morphological differentiation, and silencing of EPAC2 or CRT significantly increased senescence-associated beta-galactosidase activity with enhanced p21 expression and decreased p53 expression |
| 24169561 | These results suggest that EPAC2 and CRT are associated with cellular senescence in ESCs |
| 24169561 | Furthermore, both EPAC2 and CRT might prevent ESCs from undergoing abnormal cellular senescence during decidualization |
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