HCSGD entry for KIF3A

1. General information

Official gene symbolKIF3A
Entrez ID11127
Gene full namekinesin family member 3A
Other gene symbolsFLA10 KLP-20
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001822Kidney developmentIEAbiological_process
GO:0003777Microtubule motor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005871Kinesin complexIEAcellular_component
GO:0005874MicrotubuleIEAcellular_component
GO:0005876Spindle microtubuleIDAcellular_component
GO:0006996Organelle organizationTASbiological_process
GO:0007018Microtubule-based movementIEA TASbiological_process
GO:0007224Smoothened signaling pathwayIEAbiological_process
GO:0007368Determination of left/right symmetryIEAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008017Microtubule bindingIEAmolecular_function
GO:0008021Synaptic vesicleIEAcellular_component
GO:0008152Metabolic processTASbiological_process
GO:0008574Plus-end-directed microtubule motor activityTASmolecular_function
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0016939Kinesin II complexIDAcellular_component
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0021904Dorsal/ventral neural tube patterningIEAbiological_process
GO:0032391Photoreceptor connecting ciliumIEAcellular_component
GO:0042384Cilium assemblyISSbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0048260Positive regulation of receptor-mediated endocytosisIEAbiological_process
GO:0072372Primary ciliumISScellular_component
GO:0072383Plus-end-directed vesicle transport along microtubuleTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00842899210.92099411500.23701782701.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1898794730
GSE13712_SHEARUp0.0484191055
GSE13712_STATICUp0.1778598431
GSE19018Up0.3016711894
GSE19899_A1Up0.7747366044
GSE19899_A2Up1.4554230976
PubMed_21979375_A1Up0.4985494683
PubMed_21979375_A2Up1.4256615653
GSE35957Up0.1855044081
GSE36640Up0.9270124750
GSE54402Up0.4171526664
GSE9593Down-0.0749630115
GSE43922Up0.7274134480
GSE24585Up0.0276927565
GSE37065Down-0.1171171384
GSE28863_A1Up0.3550979303
GSE28863_A2Up0.4404088749
GSE28863_A3Down-0.4011436798
GSE28863_A4Down-0.4152199021
GSE48662Up0.2688266164

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27181777Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease
27181777The Kif3a knockout mouse is an established non-orthologous mouse model of cystic kidney disease
27181777Conditional inactivation of Kif3a in kidney tubular cells results in loss of primary cilia and rapid cyst growth
27181777Kif3a null tubular cells have unrestrained proliferation and reduced stabilization of p53 resulting in a loss of cell cycle arrest in the presence of DNA damage
27181777Interestingly, the cystic phenotype of Kif3a knockout mice is partially rescued by genetic ablation of Glis2 and pharmacological stabilization of p53
27181777Thus, Kif3a is required for cell cycle regulation and the DNA damage response, whereas cell senescence is significantly enhanced in Glis2 null cells
27181777Hence, cell senescence is a central feature in nephronophthisis type 7 and Kif3a is unexpectedly required for efficient DNA damage response and cell cycle arrest
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