HCSGD entry for PACSIN2
1. General information
| Official gene symbol | PACSIN2 |
|---|---|
| Entrez ID | 11252 |
| Gene full name | protein kinase C and casein kinase substrate in neurons 2 |
| Other gene symbols | SDPII |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005215 | Transporter activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005769 | Early endosome | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005901 | Caveola | IDA IEA | cellular_component |
| GO:0008092 | Cytoskeletal protein binding | IEA | molecular_function |
| GO:0008289 | Lipid binding | IEA | molecular_function |
| GO:0019898 | Extrinsic component of membrane | IEA ISS | cellular_component |
| GO:0030036 | Actin cytoskeleton organization | IEA | biological_process |
| GO:0030659 | Cytoplasmic vesicle membrane | IEA | cellular_component |
| GO:0032587 | Ruffle membrane | IEA | cellular_component |
| GO:0036010 | Protein localization to endosome | IMP | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0045806 | Negative regulation of endocytosis | IEA | biological_process |
| GO:0048858 | Cell projection morphogenesis | IEA ISS | biological_process |
| GO:0055038 | Recycling endosome membrane | IDA | cellular_component |
| GO:0070300 | Phosphatidic acid binding | IDA | molecular_function |
| GO:0070836 | Caveola assembly | IEA IMP | biological_process |
| GO:0072584 | Caveolin-mediated endocytosis | IMP | biological_process |
| GO:0097320 | Membrane tubulation | IDA IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8229175905 | 0.1842729266 | 0.9999902473 | 0.8326605494 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2505015344 |
| GSE13712_SHEAR | Up | 0.1167489783 |
| GSE13712_STATIC | Up | 0.2470117932 |
| GSE19018 | Down | -0.1603753896 |
| GSE19899_A1 | Down | -0.2891426794 |
| GSE19899_A2 | Down | -0.1778577713 |
| PubMed_21979375_A1 | Down | -0.0008918920 |
| PubMed_21979375_A2 | Down | -1.0420638085 |
| GSE35957 | Down | -0.0761907274 |
| GSE36640 | Down | -0.4280293849 |
| GSE54402 | Up | 0.1853382192 |
| GSE9593 | Up | 0.2014461073 |
| GSE43922 | Down | -0.0230705383 |
| GSE24585 | Up | 0.2778500308 |
| GSE37065 | Down | -0.0180489385 |
| GSE28863_A1 | Down | -0.1996297283 |
| GSE28863_A2 | Up | 0.0277264671 |
| GSE28863_A3 | Down | -0.1450926305 |
| GSE28863_A4 | Up | 0.1407136108 |
| GSE48662 | Up | 0.1250560310 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020597 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041342 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
