HCSGD entry for CHRNA7
1. General information
| Official gene symbol | CHRNA7 |
|---|---|
| Entrez ID | 1139 |
| Gene full name | cholinergic receptor, nicotinic, alpha 7 (neuronal) |
| Other gene symbols | CHRNA7-2 NACHRA7 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000187 | Activation of MAPK activity | IDA | biological_process |
| GO:0001540 | Beta-amyloid binding | IPI | molecular_function |
| GO:0001666 | Response to hypoxia | IDA | biological_process |
| GO:0004889 | Acetylcholine-activated cation-selective channel activity | IDA | molecular_function |
| GO:0005230 | Extracellular ligand-gated ion channel activity | IEA | molecular_function |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005892 | Acetylcholine-gated channel complex | IDA | cellular_component |
| GO:0006811 | Ion transport | NAS | biological_process |
| GO:0006816 | Calcium ion transport | IDA IMP | biological_process |
| GO:0006874 | Cellular calcium ion homeostasis | IMP | biological_process |
| GO:0007165 | Signal transduction | IDA | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007613 | Memory | NAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IMP | biological_process |
| GO:0015464 | Acetylcholine receptor activity | IDA | molecular_function |
| GO:0015643 | Toxic substance binding | IDA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA NAS | cellular_component |
| GO:0017081 | Chloride channel regulator activity | IDA | molecular_function |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0032720 | Negative regulation of tumor necrosis factor production | IDA IMP | biological_process |
| GO:0034220 | Ion transmembrane transport | IDA | biological_process |
| GO:0035094 | Response to nicotine | IDA | biological_process |
| GO:0042166 | Acetylcholine binding | IDA | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0045211 | Postsynaptic membrane | IEA | cellular_component |
| GO:0045766 | Positive regulation of angiogenesis | IMP | biological_process |
| GO:0050890 | Cognition | IMP NAS | biological_process |
| GO:0055085 | Transmembrane transport | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9511535732 | 0.6013036853 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.0742344519 |
| GSE28863_A2 | Down | -0.3098726051 |
| GSE28863_A3 | Up | 0.2050520368 |
| GSE28863_A4 | Up | 0.0821930450 |
| GSE48662 | Down | -0.1045119136 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016843 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
