HCSGD entry for AGAP2

1. General information

Official gene symbolAGAP2
Entrez ID116986
Gene full nameArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Other gene symbolsCENTG1 GGAP2 PIKE
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusIDA ISScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0007264Small GTPase mediated signal transductionIEAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008060ARF GTPase activator activityIEAmolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0015031Protein transportIEAbiological_process
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0030295Protein kinase activator activityIEAmolecular_function
GO:0032312Regulation of ARF GTPase activityIEAbiological_process
GO:0033601Positive regulation of mammary gland epithelial cell proliferationIEAbiological_process
GO:0042177Negative regulation of protein catabolic processIDAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIGIbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046427Positive regulation of JAK-STAT cascadeIEAbiological_process
GO:0060749Mammary gland alveolus developmentIEAbiological_process
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.88940645110.52713603210.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1151975172
GSE13712_SHEARDown-0.0756019242
GSE13712_STATICDown-0.0666318799
GSE19018Up0.0530103644
GSE19899_A1Down-0.0671164314
GSE19899_A2Up0.0199894273
PubMed_21979375_A1Down-0.3055563368
PubMed_21979375_A2Down-0.1574613299
GSE35957Up0.0629212826
GSE36640Down-0.0675294491
GSE54402Up0.0450379541
GSE9593Up0.0716293760
GSE43922Up0.1337835859
GSE24585Up0.0952800445
GSE37065Down-0.1468683992
GSE28863_A1Down-0.1919907168
GSE28863_A2Down-0.2176704938
GSE28863_A3Up0.2171958990
GSE28863_A4Up0.1122538591
GSE48662Up0.0837410417

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.