HCSGD entry for TWIST2

1. General information

Official gene symbolTWIST2
Entrez ID117581
Gene full nametwist basic helix-loop-helix transcription factor 2
Other gene symbolsDERMO1 FFDD3 SETLSS bHLHa39
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001076RNA polymerase II transcription factor binding transcription factor activityIEAmolecular_function
GO:0001649Osteoblast differentiationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0010838Positive regulation of keratinocyte proliferationIEAbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0032720Negative regulation of tumor necrosis factor productionIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043392Negative regulation of DNA bindingIEAbiological_process
GO:0045638Negative regulation of myeloid cell differentiationIEAbiological_process
GO:0045668Negative regulation of osteoblast differentiationIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0048701Embryonic cranial skeleton morphogenesisIEAbiological_process
GO:0060325Face morphogenesisIEAbiological_process
GO:0061303Cornea development in camera-type eyeIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66755727370.02125613770.99999024730.2822599092

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2260487864
GSE13712_SHEARDown-1.6929114017
GSE13712_STATICDown-1.0858417776
GSE19018Down-0.0192409203
GSE19899_A1Down-0.0597132397
GSE19899_A2Up0.4734364988
PubMed_21979375_A1Down-1.0000601863
PubMed_21979375_A2Up0.0352001323
GSE35957Up0.4497798961
GSE36640Down-0.7252186563
GSE54402Up0.4506181697
GSE9593Down-0.2829848724
GSE43922Down-0.0040328892
GSE24585Down-0.1656700787
GSE37065Up0.3906942727
GSE28863_A1Down-0.5249262166
GSE28863_A2Up0.0427173571
GSE28863_A3Up0.0693545482
GSE28863_A4Down-0.4895485011
GSE48662Down-0.0460873484

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT002714Microarray//Microarray;OtherFunctional MTI (Weak)15685193
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.