HCSGD entry for SERPINA3

1. General information

Official gene symbolSERPINA3
Entrez ID12
Gene full nameserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Other gene symbolsAACT ACT GIG25
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003677DNA bindingTASmolecular_function
GO:0004867Serine-type endopeptidase inhibitor activityIBA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIBA NAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005622IntracellularNAScellular_component
GO:0005634NucleusTAScellular_component
GO:0006953Acute-phase responseIEAbiological_process
GO:0006954Inflammatory responseNASbiological_process
GO:0010951Negative regulation of endopeptidase activityIBAbiological_process
GO:0019216Regulation of lipid metabolic processNASbiological_process
GO:0030162Regulation of proteolysisIBAbiological_process
GO:0030277Maintenance of gastrointestinal epitheliumNASbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13280557350.90962651120.73783098351.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1072099297
GSE13712_SHEARUp0.2462532542
GSE13712_STATICDown-0.0163562337
GSE19018Up0.0377174934
GSE19899_A1Up0.0193825499
GSE19899_A2Up0.1383705208
PubMed_21979375_A1Up0.3794969322
PubMed_21979375_A2Up0.0733093494
GSE35957Down-0.1979094413
GSE36640Up0.1228866293
GSE54402Down-0.0898409862
GSE9593Up0.5045752935
GSE43922Up0.0113561598
GSE24585Up0.4254853965
GSE37065Up0.4310342431
GSE28863_A1Up0.0424496313
GSE28863_A2Down-0.0130198244
GSE28863_A3Up0.2322519221
GSE28863_A4Down-0.1305907952
GSE48662Up0.5535061421

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016786MicroarrayFunctional MTI (Weak)18185580
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.