HCSGD entry for ACVR1C
1. General information
| Official gene symbol | ACVR1C |
|---|---|
| Entrez ID | 130399 |
| Gene full name | activin A receptor, type IC |
| Other gene symbols | ACVRLK7 ALK7 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002021 | Response to dietary excess | IEA | biological_process |
| GO:0005024 | Transforming growth factor beta-activated receptor activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | IC | biological_process |
| GO:0009749 | Response to glucose | IEA | biological_process |
| GO:0016361 | Activin receptor activity, type I | IDA | molecular_function |
| GO:0019915 | Lipid storage | IEA | biological_process |
| GO:0030154 | Cell differentiation | IDA | biological_process |
| GO:0030262 | Apoptotic nuclear changes | IDA | biological_process |
| GO:0032868 | Response to insulin | IEA | biological_process |
| GO:0038092 | Nodal signaling pathway | IMP | biological_process |
| GO:0038100 | Nodal binding | IMP | molecular_function |
| GO:0043280 | Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | IMP | biological_process |
| GO:0046676 | Negative regulation of insulin secretion | IEA | biological_process |
| GO:0046872 | Metal ion binding | IC | molecular_function |
| GO:0048179 | Activin receptor complex | IDA | cellular_component |
| GO:1901164 | Negative regulation of trophoblast cell migration | IDA | biological_process |
| GO:1901383 | Negative regulation of chorionic trophoblast cell proliferation | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1714227347 | 0.8825005357 | 0.8136467640 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0595881821 |
| GSE13712_SHEAR | Up | 0.0699623231 |
| GSE13712_STATIC | Up | 0.1876593605 |
| GSE19018 | Down | -0.0377690768 |
| GSE19899_A1 | Up | 0.2487625815 |
| GSE19899_A2 | Up | 0.3592657113 |
| PubMed_21979375_A1 | Up | 0.1350304664 |
| PubMed_21979375_A2 | Up | 0.1178834494 |
| GSE35957 | Down | -0.3289838807 |
| GSE36640 | Up | 0.2577436136 |
| GSE54402 | Up | 0.0169420098 |
| GSE9593 | Down | -0.9722686263 |
| GSE43922 | Up | 0.0417803997 |
| GSE24585 | Up | 0.8716265175 |
| GSE37065 | Up | 0.1114966888 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0424161272 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-376c-3p | MIMAT0000720 | MIRT005775 | Luciferase reporter assay//Western blot//Reporter assay;Western blot;qRT-PCR | Functional MTI | 21224400 |
| hsa-miR-376a-3p | MIMAT0000729 | MIRT005776 | Luciferase reporter assay//Reporter assay;Western blot | Non-Functional MTI | 21224400 |
| hsa-miR-376a-5p | MIMAT0003386 | MIRT005777 | Luciferase reporter assay//Reporter assay;Western blot | Non-Functional MTI | 21224400 |
| hsa-miR-376b-3p | MIMAT0002172 | MIRT005778 | Luciferase reporter assay//Reporter assay;Western blot | Non-Functional MTI | 21224400 |
| hsa-miR-22-3p | MIMAT0000077 | MIRT005779 | Luciferase reporter assay//Western blot//Reporter assay;Western blot | Non-Functional MTI | 21224400 |
| hsa-miR-412-3p | MIMAT0002170 | MIRT005780 | Luciferase reporter assay//Reporter assay | Non-Functional MTI | 21224400 |
| hsa-miR-147a | MIMAT0000251 | MIRT005781 | Luciferase reporter assay//Reporter assay | Non-Functional MTI | 21224400 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT005782 | Luciferase reporter assay//Reporter assay | Non-Functional MTI | 21224400 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
