HCSGD entry for CRP

1. General information

Official gene symbolCRP
Entrez ID1401
Gene full nameC-reactive protein, pentraxin-related
Other gene symbolsPTX1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionNAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006953Acute-phase responseTASbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0006958Complement activation, classical pathwayIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0008228OpsonizationTASbiological_process
GO:0010288Response to lead ionIEAbiological_process
GO:0010745Negative regulation of macrophage derived foam cell differentiationIDAbiological_process
GO:0010888Negative regulation of lipid storageIDAbiological_process
GO:0015485Cholesterol bindingIEAmolecular_function
GO:0030169Low-density lipoprotein particle bindingIDAmolecular_function
GO:0030175FilopodiumIEAcellular_component
GO:0030426Growth coneIEAcellular_component
GO:0033265Choline bindingTASmolecular_function
GO:0042060Wound healingIEAbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0045471Response to ethanolIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050830Defense response to Gram-positive bacteriumTASbiological_process
GO:0051258Protein polymerizationIEAbiological_process
GO:0071277Cellular response to calcium ionIEAbiological_process
GO:1900006Positive regulation of dendrite developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.73670951710.82181038330.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0432807124
GSE13712_SHEARUp0.1085252193
GSE13712_STATICUp0.1104652299
GSE19018Up0.0269813637
GSE19899_A1Down-0.0381844379
GSE19899_A2Down-0.0370311122
PubMed_21979375_A1Down-0.0646669421
PubMed_21979375_A2Down-0.1270890328
GSE35957Up0.0707174286
GSE36640Up0.0148924978
GSE54402Down-0.0328055735
GSE9593Down-0.0186694281
GSE43922Up0.0185154424
GSE24585Down-0.1283344417
GSE37065Down-0.0029104593
GSE28863_A1Up0.0761662896
GSE28863_A2Down-0.0157234508
GSE28863_A3Up0.3229092440
GSE28863_A4Down-0.0478074998
GSE48662Up0.2165260402

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PhosphocholineDB03945 EXPT02629
CRx-139DB05744 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 10 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27156058These associations were independent of age, gender, cardiovascular risk factors, circulating levels of CRP and medication differences
26340803All subjects were free of infection according to the C reactive protein (CRP) value and routine peripheral blood profile
25574956Markers of T-cell activation and senescence were determined by flow cytometry, and plasma levels of interleukin-6, interleukin-8, and C-reactive protein (CRP) were measured, as was telomere length of peripheral blood mononuclear cells (PBMC)
25574956RESULTS: Activated CD25(+) T cells and activated/senescent CD69(+)/CD57(+)/CD28(null) CD4(+) T cells, interleukin-6, and CRP were associated with PFT abnormalities
23853351The increased frequencies of CRP ATG haplotypes and CFH 402 His allele indicate high mortality in the elderly
23050148The transcription rate of these genes was also measured after the cultivation of PBMCs under four different conditions: just with the culture medium, with lipopolysaccharide (LPS), with C-reactive protein (CRP), and with lipoxin A(4) (LXA(4))-LPS
22663935We confirmed the importance of inflammatory markers (IL-6, TNF-alpha, CRP, neutrophils) in frailty in the very old, previously established only in younger-old populations
22206234BACKGROUND: Levels of complement regulatory proteins (CrP) on the surface of red blood cells (RBC) decrease during severe malarial anaemia and as part of cell ageing process
22206234It remains unclear whether CrP changes seen during malaria contribute to the development of anaemia, or result from an altered RBC age distribution due to suppressive effects of malaria on erythropoiesis
21602933METHODOLOGY/PRINCIPAL FINDINGS: To address this issue, we examined if individuals with high levels of the systemic inflammatory markers interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and C-reactive protein (CRP) had increased odds for short LTL
21602933In contrast, CRP was not associated with LTL
21602933In contrast, high levels of CRP were not accompanied by short LTL in this cohort of older adults
15956081Moreover, we assessed whether the serum level of C-reactive protein (CRP), a marker for systemic inflammation, was associated with cellular impairment of EPCs
15956081Patients with preeclampsia were divided into two subgroups: the CRP-negative group (CRP, <0
159560811 mg/dl; n = 4) and the CRP-positive group (CRP, > or =0
159560811 mg/dl; n = 4) and the CRP-positive group (CRP, > or =0
15095782Exposure of phosphatidylserine is not a primary signal for RBC removal and where exposed it initiates binding of CRP or of beta-2-glycoprotein I and NAbs
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