HCSGD entry for CRYAA

1. General information

Official gene symbolCRYAA
Entrez ID1409
Gene full namecrystallin, alpha A
Other gene symbolsCRYA1 CTRCT9 HSPB4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIEAbiological_process
GO:0005212Structural constituent of eye lensIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0007005Mitochondrion organizationIEAbiological_process
GO:0007015Actin filament organizationIEAbiological_process
GO:0007021Tubulin complex assemblyIEAbiological_process
GO:0007601Visual perceptionIMPbiological_process
GO:0010288Response to lead ionIEAbiological_process
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0030307Positive regulation of cell growthIEAbiological_process
GO:0032387Negative regulation of intracellular transportIDAbiological_process
GO:0042026Protein refoldingISSbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043066Negative regulation of apoptotic processIDA IMPbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048596Embryonic camera-type eye morphogenesisIEAbiological_process
GO:0051082Unfolded protein bindingIMP IPImolecular_function
GO:0051260Protein homooligomerizationIDAbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0060561Apoptotic process involved in morphogenesisIEAbiological_process
GO:0070141Response to UV-AIEAbiological_process
GO:0070309Lens fiber cell morphogenesisIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.56771889370.78581617720.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1525019958
GSE13712_SHEARDown-0.0042770495
GSE13712_STATICDown-0.0136017143
GSE19018Up0.0051242222
GSE19899_A1Down-0.0976664272
GSE19899_A2Up0.0103266809
PubMed_21979375_A1Down-0.0978174508
PubMed_21979375_A2Down-0.1654071079
GSE35957Up0.3582097295
GSE36640Up0.0416430422
GSE54402Up0.1684677982
GSE9593Up0.0121140624
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.0030771853
GSE28863_A2Up0.0240128587
GSE28863_A3Up0.4627977293
GSE28863_A4Up0.0731338648
GSE48662Down-0.1552573330

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34a-5pMIMAT0000255MIRT025225ProteomicsFunctional MTI (Weak)21566225
hsa-miR-26b-5pMIMAT0000083MIRT030179MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.