HCSGD entry for CTNS
1. General information
| Official gene symbol | CTNS |
|---|---|
| Entrez ID | 1497 |
| Gene full name | cystinosin, lysosomal cystine transporter |
| Other gene symbols | CTNS-LSB PQLC4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003333 | Amino acid transmembrane transport | IMP NAS | biological_process |
| GO:0005764 | Lysosome | IDA IEA | cellular_component |
| GO:0005765 | Lysosomal membrane | IDA NAS | cellular_component |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0005770 | Late endosome | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006520 | Cellular amino acid metabolic process | NAS | biological_process |
| GO:0006749 | Glutathione metabolic process | IMP | biological_process |
| GO:0007420 | Brain development | IMP | biological_process |
| GO:0007616 | Long-term memory | IEA | biological_process |
| GO:0007625 | Grooming behavior | IEA | biological_process |
| GO:0007628 | Adult walking behavior | IEA | biological_process |
| GO:0008542 | Visual learning | IEA | biological_process |
| GO:0015184 | L-cystine transmembrane transporter activity | IEA IMP NAS | molecular_function |
| GO:0015811 | L-cystine transport | IDA IMP NAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0034220 | Ion transmembrane transport | IMP NAS | biological_process |
| GO:0046034 | ATP metabolic process | IMP | biological_process |
| GO:0048058 | Compound eye corneal lens development | IEA | biological_process |
| GO:0050890 | Cognition | IMP | biological_process |
| GO:0055085 | Transmembrane transport | IMP NAS | biological_process |
| GO:1902475 | L-alpha-amino acid transmembrane transport | IMP NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0037453934 | 0.9692752669 | 0.1640915282 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4911932106 |
| GSE13712_SHEAR | Down | -0.9836199707 |
| GSE13712_STATIC | Down | -0.4277295928 |
| GSE19018 | Up | 0.0360657655 |
| GSE19899_A1 | Up | 0.3871414140 |
| GSE19899_A2 | Up | 0.9777995354 |
| PubMed_21979375_A1 | Up | 1.4589221306 |
| PubMed_21979375_A2 | Up | 1.9196784208 |
| GSE35957 | Up | 0.3158569782 |
| GSE36640 | Up | 0.6183564707 |
| GSE54402 | Up | 0.6259146145 |
| GSE9593 | Up | 0.9494988280 |
| GSE43922 | Up | 0.4700777447 |
| GSE24585 | Up | 0.2229304528 |
| GSE37065 | Up | 0.3313592158 |
| GSE28863_A1 | Up | 0.1246575003 |
| GSE28863_A2 | Up | 0.3934734351 |
| GSE28863_A3 | Down | -0.1206378916 |
| GSE28863_A4 | Down | -0.1827986889 |
| GSE48662 | Up | 0.2758808226 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Cystine | DB00138 | NUTR00023 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022765 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029732 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-320a | MIMAT0000510 | MIRT044666 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
