HCSGD entry for CTPS1
1. General information
| Official gene symbol | CTPS1 |
|---|---|
| Entrez ID | 1503 |
| Gene full name | CTP synthase 1 |
| Other gene symbols | CTPS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003883 | CTP synthase activity | EXP IDA IEA IGI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006139 | Nucleobase-containing compound metabolic process | TAS | biological_process |
| GO:0006221 | Pyrimidine nucleotide biosynthetic process | IEA | biological_process |
| GO:0006241 | CTP biosynthetic process | IDA | biological_process |
| GO:0006541 | Glutamine metabolic process | IEA | biological_process |
| GO:0015949 | Nucleobase-containing small molecule interconversion | TAS | biological_process |
| GO:0042493 | Response to drug | TAS | biological_process |
| GO:0044210 | 'de novo' CTP biosynthetic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0859254094 | 0.0411989628 | 0.6150782431 | 0.3824144570 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.9966728524 |
| GSE13712_SHEAR | Up | 0.4919030037 |
| GSE13712_STATIC | Up | 0.2638111595 |
| GSE19018 | Down | -1.7160392221 |
| GSE19899_A1 | Up | 0.5150524509 |
| GSE19899_A2 | Up | 0.0247044083 |
| PubMed_21979375_A1 | Up | 0.7044788535 |
| PubMed_21979375_A2 | Up | 0.3009915169 |
| GSE35957 | Up | 0.0566257871 |
| GSE36640 | Up | 0.4425758412 |
| GSE54402 | Up | 0.7349745964 |
| GSE9593 | Down | -0.8508041049 |
| GSE43922 | Up | 0.6030302509 |
| GSE24585 | Down | -0.3862958136 |
| GSE37065 | Down | -0.3608548842 |
| GSE28863_A1 | Down | -0.3547255017 |
| GSE28863_A2 | Up | 0.1636549277 |
| GSE28863_A3 | Down | -0.1444658816 |
| GSE28863_A4 | Down | -0.1331305900 |
| GSE48662 | Down | -0.3272407807 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023253 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032244 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040360 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042068 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044690 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044987 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052704 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25523786 | The analysis of in vitro cell senescence/growth after serial passaging can be one of ways to show the absence of immortalized cells, which are frequently tumorigenic, in human cell-processed therapeutic products (hCTPs) |
| 25523786 | These findings suggest that the cell growth analysis is a simple and sensitive method to detect immortalized cellular impurities in hCTPs derived from human somatic cells |
| 18206730 | Here, we describe in vitro and in vivo validation of the phase I/II protocol for CD34+ expansion of thawed CB units according to the current Cell Therapy Products (CTPs) Guidelines |
| 18206730 | In vivo data demonstrated that after culture, the final CTPs maintain their repopulating ability in nonobese diabetic severe combined immunodeficient (SCID) mice |
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