HCSGD entry for DAB2IP

1. General information

Official gene symbolDAB2IP
Entrez ID153090
Gene full nameDAB2 interacting protein
Other gene symbolsAF9Q34 AIP1 DIP1/2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0000185Activation of MAPKKK activityIDAbiological_process
GO:0001525AngiogenesisIEAbiological_process
GO:0001933Negative regulation of protein phosphorylationIMP ISSbiological_process
GO:0005099Ras GTPase activator activityIBA IEA ISSmolecular_function
GO:0005123Death receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006927Transformed cell apoptotic processTASbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0006986Response to unfolded proteinIEAbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007252I-kappaB phosphorylationIEA ISSbiological_process
GO:0007257Activation of JUN kinase activityIDAbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsIMPbiological_process
GO:0010596Negative regulation of endothelial cell migrationIEA IMPbiological_process
GO:0010633Negative regulation of epithelial cell migrationIMP TASbiological_process
GO:0010719Negative regulation of epithelial to mesenchymal transitionIDA IMPbiological_process
GO:0010976Positive regulation of neuron projection developmentISSbiological_process
GO:0014067Negative regulation of phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0016525Negative regulation of angiogenesisIDA IEAbiological_process
GO:0017124SH3 domain bindingIDAmolecular_function
GO:0019900Kinase bindingIPImolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0021814Cell motility involved in cerebral cortex radial glia guided migrationIEA ISSbiological_process
GO:0021819Layer formation in cerebral cortexIEA ISSbiological_process
GO:0030139Endocytic vesicleIDAcellular_component
GO:0030308Negative regulation of cell growthIEAbiological_process
GO:0030424AxonISScellular_component
GO:0030425DendriteIEAcellular_component
GO:0030948Negative regulation of vascular endothelial growth factor receptor signaling pathwayIEA IMPbiological_process
GO:0031235Intrinsic component of the cytoplasmic side of the plasma membraneIBAcellular_component
GO:0031434Mitogen-activated protein kinase kinase bindingIPImolecular_function
GO:0031435Mitogen-activated protein kinase kinase kinase bindingIPImolecular_function
GO:0032088Negative regulation of NF-kappaB transcription factor activityIMPbiological_process
GO:0032266Phosphatidylinositol-3-phosphate bindingIDAmolecular_function
GO:0032312Regulation of ARF GTPase activityIEA ISSbiological_process
GO:0032320Positive regulation of Ras GTPase activityIBAbiological_process
GO:0032403Protein complex bindingIDAmolecular_function
GO:0032809Neuronal cell body membraneIEA ISScellular_component
GO:0034144Negative regulation of toll-like receptor 4 signaling pathwayIDAbiological_process
GO:0034260Negative regulation of GTPase activityIEA ISSbiological_process
GO:0034261Negative regulation of Ras GTPase activityIMPbiological_process
GO:0035148Tube formationIEA IMPbiological_process
GO:0035414Negative regulation of catenin import into nucleusIEA ISSbiological_process
GO:0035591Signaling adaptor activityIDAmolecular_function
GO:0035662Toll-like receptor 4 bindingIDAmolecular_function
GO:0035924Cellular response to vascular endothelial growth factor stimulusIDA IEA ISSbiological_process
GO:0036312Phosphatidylinositol 3-kinase regulatory subunit bindingIDAmolecular_function
GO:0036324Vascular endothelial growth factor receptor-2 signaling pathwayIEA ISSbiological_process
GO:0042059Negative regulation of epidermal growth factor receptor signaling pathwayIEA ISSbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043025Neuronal cell bodyISScellular_component
GO:0043065Positive regulation of apoptotic processIDA IEAbiological_process
GO:0043122Regulation of I-kappaB kinase/NF-kappaB signalingIEA ISSbiological_process
GO:0043124Negative regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0043184Vascular endothelial growth factor receptor 2 bindingIPImolecular_function
GO:0043254Regulation of protein complex assemblyIDA IEAbiological_process
GO:0043407Negative regulation of MAP kinase activityIDA IMPbiological_process
GO:0043410Positive regulation of MAPK cascadeIDAbiological_process
GO:0043507Positive regulation of JUN kinase activityIDA IEAbiological_process
GO:0043548Phosphatidylinositol 3-kinase bindingIDAmolecular_function
GO:0043553Negative regulation of phosphatidylinositol 3-kinase activityIDAbiological_process
GO:0044257Cellular protein catabolic processIDAbiological_process
GO:0044300Cerebellar mossy fiberIEA ISScellular_component
GO:0044301Climbing fiberIEA ISScellular_component
GO:0045087Innate immune responseIEAbiological_process
GO:0045732Positive regulation of protein catabolic processIEA ISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046330Positive regulation of JNK cascadeIDAbiological_process
GO:0046580Negative regulation of Ras protein signal transductionIBA IC IEAbiological_process
GO:0047485Protein N-terminus bindingIEAmolecular_function
GO:0048147Negative regulation of fibroblast proliferationIEA ISSbiological_process
GO:0048812Neuron projection morphogenesisIEA ISSbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIMPbiological_process
GO:0051721Protein phosphatase 2A bindingIDAmolecular_function
GO:0070059Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIEA ISSbiological_process
GO:0070273Phosphatidylinositol-4-phosphate bindingIDAmolecular_function
GO:0070317Negative regulation of G0 to G1 transitionIDAbiological_process
GO:0070373Negative regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0071158Positive regulation of cell cycle arrestIDAbiological_process
GO:0071222Cellular response to lipopolysaccharideIDA IEAbiological_process
GO:0071347Cellular response to interleukin-1IDA IEAbiological_process
GO:0071356Cellular response to tumor necrosis factorIDA IEAbiological_process
GO:0071364Cellular response to epidermal growth factor stimulusIEA ISSbiological_process
GO:007188914-3-3 protein bindingIDAmolecular_function
GO:0071901Negative regulation of protein serine/threonine kinase activityIDA IEA IMPbiological_process
GO:0071902Positive regulation of protein serine/threonine kinase activityIDA IMPbiological_process
GO:0072577Endothelial cell apoptotic processTASbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIMPbiological_process
GO:0090129Positive regulation of synapse maturationIEA ISSbiological_process
GO:1900006Positive regulation of dendrite developmentIEA ISSbiological_process
GO:1900744Regulation of p38MAPK cascadeIEA ISSbiological_process
GO:1900747Negative regulation of vascular endothelial growth factor signaling pathwayIEA ISSbiological_process
GO:1901800Positive regulation of proteasomal protein catabolic processIMPbiological_process
GO:1990032Parallel fiberIEA ISScellular_component
GO:2000599Negative regulation of cyclin catabolic processIDAbiological_process
GO:2001224Positive regulation of neuron migrationIEA ISSbiological_process
GO:2001235Positive regulation of apoptotic signaling pathwayIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.60336834470.50116730750.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0815754409
GSE13712_SHEARDown-0.0571761719
GSE13712_STATICDown-0.2591132563
GSE19018Up0.0098113277
GSE19899_A1Down-0.0492776016
GSE19899_A2Up0.1464712913
PubMed_21979375_A1Down-0.3147830714
PubMed_21979375_A2Down-0.0352444470
GSE35957Up0.1397668504
GSE36640Up0.1349240262
GSE54402Down-0.6163090193
GSE9593Up0.0358224749
GSE43922Up0.0274710560
GSE24585Down-0.1688941146
GSE37065Up0.0893795953
GSE28863_A1Up0.0652455169
GSE28863_A2Up0.3054999038
GSE28863_A3Up0.3058688300
GSE28863_A4Up0.0139642258
GSE48662Up0.0762480763

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-338-3pMIMAT0000763MIRT003041qRT-PCR//Western blotFunctional MTI18684991
hsa-miR-18a-3pMIMAT0002891MIRT040771CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052296CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24073285Downregulation of DAB2IP promotes mesenchymal-to-neuroepithelial transition and neuronal differentiation of human mesenchymal stem cells
24073285The DOC-2/DAB2 interactive protein (DAB2IP) is a new member of the Ras GTPase-activating protein family
24073285Recent studies have shown that, in addition to its tumor suppressive role in various tumors, DAB2IP also plays an important role in regulating neuronal migration and positioning during brain development
24073285In this study, we determined the roles of DAB2IP in the neuronal differentiation of human mesenchymal stem cells (hMSCs)
24073285We found that lentiviral short hairpin RNA (shRNA)-mediated knockdown of DAB2IP promoted the mesenchymal-to-neuroepithelial stem cell transition (MtNeST) and neuronal differentiation, which were accompanied by a reduction of cell proliferation but not apoptosis or cellular senescence
24073285This suggests that DAB2IP plays an important role in the neuronal induction of hMSCs
24073285Moreover, our finding that reduction of glycogen synthase kinase 3 beta (GSK3beta) activity upon LiCl pretreatment inhibited both the MtNeST and production of MAP2-positive cells upon DAB2IP knockdown suggests that this transition is most likely mediated by regulation of the GSK3beta signaling pathway
24073285Our study demonstrates that DAB2IP participates in the first step of neuron induction of hMSCs, which implies a potentially important role for DAB2IP in the MtNeST during neurogenesis
Entries Per Page
Displaying Page of