HCSGD entry for ADRB2

1. General information

Official gene symbolADRB2
Entrez ID154
Gene full nameadrenoceptor beta 2, surface
Other gene symbolsADRB2R ADRBR B2AR BAR BETA2AR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002024Diet induced thermogenesisIEAbiological_process
GO:0002025Vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureIEAbiological_process
GO:0002028Regulation of sodium ion transportIEAbiological_process
GO:0002032Desensitization of G-protein coupled receptor protein signaling pathway by arrestinIDAbiological_process
GO:0004941Beta2-adrenergic receptor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005764LysosomeTAScellular_component
GO:0005768EndosomeTAScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006898Receptor-mediated endocytosisIDAbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007171Activation of transmembrane receptor protein tyrosine kinase activityTASbiological_process
GO:0007188Adenylate cyclase-modulating G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007190Activation of adenylate cyclase activityIDAbiological_process
GO:0008179Adenylate cyclase bindingIEAmolecular_function
GO:0008333Endosome to lysosome transportTASbiological_process
GO:0009409Response to coldIEAbiological_process
GO:0015459Potassium channel regulator activityIDAmolecular_function
GO:0016324Apical plasma membraneIEAcellular_component
GO:0030501Positive regulation of bone mineralizationIEAbiological_process
GO:0031398Positive regulation of protein ubiquitinationIMPbiological_process
GO:0031649Heat generationIEAbiological_process
GO:0040015Negative regulation of multicellular organism growthIEAbiological_process
GO:0042312Regulation of vasodilationIEAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043235Receptor complexIDAcellular_component
GO:0043410Positive regulation of MAPK cascadeIDAbiological_process
GO:0045453Bone resorptionIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0045986Negative regulation of smooth muscle contractionIEAbiological_process
GO:0050873Brown fat cell differentiationIEAbiological_process
GO:0051380Norepinephrine bindingIDAmolecular_function
GO:0071875Adrenergic receptor signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05079078680.73928396720.49372177931.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0259160292
GSE13712_SHEARUp0.5487782246
GSE13712_STATICUp0.6703280847
GSE19018Up0.6301662345
GSE19899_A1Down-0.0974476463
GSE19899_A2Up0.1722293093
PubMed_21979375_A1Up0.7718912820
PubMed_21979375_A2Up0.1720919763
GSE35957Down-1.1649438542
GSE36640Up1.0097954554
GSE54402Down-0.3173438694
GSE9593Up0.0236554349
GSE43922Down-0.0054495146
GSE24585Up0.1536363928
GSE37065Up0.0440826898
GSE28863_A1Down-0.0659691852
GSE28863_A2Up0.1922841062
GSE28863_A3Up0.3334725630
GSE28863_A4Up0.1445865737
GSE48662Down-0.6752607701

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.