HCSGD entry for CDCA2
1. General information
| Official gene symbol | CDCA2 |
|---|---|
| Entrez ID | 157313 |
| Gene full name | cell division cycle associated 2 |
| Other gene symbols | Repo-Man |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0007067 | Mitosis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8631212112 | 0.0001387675 | 0.9999902473 | 0.0206355932 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4123404146 |
| GSE13712_SHEAR | Down | -0.6332659440 |
| GSE13712_STATIC | Up | 0.1028923016 |
| GSE19018 | Up | 0.2010889733 |
| GSE19899_A1 | Down | -0.7334095995 |
| GSE19899_A2 | Down | -3.7255728852 |
| PubMed_21979375_A1 | Down | -1.4572340581 |
| PubMed_21979375_A2 | Down | -2.4681659527 |
| GSE35957 | Down | -1.2956004769 |
| GSE36640 | Down | -4.9008564898 |
| GSE54402 | Down | -1.1179331064 |
| GSE9593 | Down | -0.3306877126 |
| GSE43922 | Down | -1.3411020170 |
| GSE24585 | Down | -0.1105231954 |
| GSE37065 | Down | -0.4156760930 |
| GSE28863_A1 | Up | 0.3137846719 |
| GSE28863_A2 | Up | 1.3145661978 |
| GSE28863_A3 | Down | -0.5302735407 |
| GSE28863_A4 | Down | -0.0410680493 |
| GSE48662 | Down | -2.1174432646 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016459 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040857 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24905922 | Results allowed us to identify Cell Division Cycle Associated 2 (CDCA2) and Inhibitor of DNA binding/differentiation type 4 (ID4) as novel targets of SAmiR-494 and SAmiR-486-5p, respectively |
| 24905922 | Furthermore, we demonstrated that the over-expression of CDCA2 in human primary fibroblasts was able to partially counteract etoposide-induced senescence by mitigating the activation of DNA Damage Response |
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