HCSGD entry for CYP27A1
1. General information
| Official gene symbol | CYP27A1 |
|---|---|
| Entrez ID | 1593 |
| Gene full name | cytochrome P450, family 27, subfamily A, polypeptide 1 |
| Other gene symbols | CP27 CTX CYP27 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006699 | Bile acid biosynthetic process | TAS | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0008203 | Cholesterol metabolic process | IEA | biological_process |
| GO:0008206 | Bile acid metabolic process | TAS | biological_process |
| GO:0008395 | Steroid hydroxylase activity | TAS | molecular_function |
| GO:0016125 | Sterol metabolic process | TAS | biological_process |
| GO:0016705 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEA | molecular_function |
| GO:0020037 | Heme binding | IEA | molecular_function |
| GO:0030343 | Vitamin D3 25-hydroxylase activity | IEA | molecular_function |
| GO:0031073 | Cholesterol 26-hydroxylase activity | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0047749 | Cholestanetriol 26-monooxygenase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1944097527 | 0.2136049124 | 0.8540877003 | 0.8926063978 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1814507565 |
| GSE13712_SHEAR | Down | -0.2926880991 |
| GSE13712_STATIC | Up | 0.0845820160 |
| GSE19018 | Up | 0.0089899830 |
| GSE19899_A1 | Down | -0.2653298937 |
| GSE19899_A2 | Up | 0.0457660903 |
| PubMed_21979375_A1 | Down | -0.7773403566 |
| PubMed_21979375_A2 | Down | -0.1983843789 |
| GSE35957 | Down | -0.1315517653 |
| GSE36640 | Down | -0.3388262883 |
| GSE54402 | Down | -0.2099439899 |
| GSE9593 | Down | -0.0656989446 |
| GSE43922 | Down | -0.4407074269 |
| GSE24585 | Up | 0.6303069961 |
| GSE37065 | Up | 0.2114707082 |
| GSE28863_A1 | Up | 0.5500522036 |
| GSE28863_A2 | Up | 0.7824153178 |
| GSE28863_A3 | Up | 0.1657405977 |
| GSE28863_A4 | Down | -0.1001881735 |
| GSE48662 | Up | 0.4074486664 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27036870 | Similarly, expression of sterol 27-hydroxylase was significantly upregulated in lung fibroblasts and alveolar macrophages in these patients |
| 23257424 | This study was purposed to investigate the effect of chemotherapeutic drug cyclophosphamide (CTX) on normal murine bone marrow hematopoietic cells, especially on the self-renewal, proliferation and differentiation of bone marrow hematopoietic cells, and possible mechanisms |
| 23257424 | The CTX-treated mouse model was established by CTX 200 mg/kg, ip |
| 23257424 | The potential effect of CTX on senescence of bone marrow hematopoietic cells was analyzed by detecting p16(Ink4a) mRNA relative expression and SA-beta-galactosidase (gal) staining |
| 23257424 | The results showed that the CTX could induce long-term but latent damage to bone marrow hematopoietic cell function and lead to the decrease in competency of bone marrow hematopoietic cells to reconstitute while seemingly permitting a complete recovery |
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