HCSGD entry for DLD
1. General information
| Official gene symbol | DLD |
|---|---|
| Entrez ID | 1738 |
| Gene full name | dihydrolipoamide dehydrogenase |
| Other gene symbols | DLDD DLDH E3 GCSL LAD PHE3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004148 | Dihydrolipoyl dehydrogenase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005929 | Cilium | IEA | cellular_component |
| GO:0006090 | Pyruvate metabolic process | TAS | biological_process |
| GO:0006099 | Tricarboxylic acid cycle | TAS | biological_process |
| GO:0006120 | Mitochondrial electron transport, NADH to ubiquinone | IEA | biological_process |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006554 | Lysine catabolic process | TAS | biological_process |
| GO:0007369 | Gastrulation | IEA | biological_process |
| GO:0009083 | Branched-chain amino acid catabolic process | TAS | biological_process |
| GO:0010510 | Regulation of acetyl-CoA biosynthetic process from pyruvate | TAS | biological_process |
| GO:0016668 | Oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor | IEA | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042391 | Regulation of membrane potential | IEA | biological_process |
| GO:0043159 | Acrosomal matrix | IEA | cellular_component |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045454 | Cell redox homeostasis | IEA | biological_process |
| GO:0048240 | Sperm capacitation | IEA | biological_process |
| GO:0050660 | Flavin adenine dinucleotide binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5312790016 | 0.4032084609 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1580199775 |
| GSE13712_SHEAR | Up | 0.2186780197 |
| GSE13712_STATIC | Up | 0.2821965619 |
| GSE19018 | Down | -0.5196551051 |
| GSE19899_A1 | Up | 0.1495295527 |
| GSE19899_A2 | Down | -0.0031384634 |
| PubMed_21979375_A1 | Up | 0.3413831712 |
| PubMed_21979375_A2 | Up | 0.1899394312 |
| GSE35957 | Down | -0.1309424178 |
| GSE36640 | Up | 0.1236039782 |
| GSE54402 | Up | 0.1396007388 |
| GSE9593 | Down | -0.2624712445 |
| GSE43922 | Down | -0.0732216373 |
| GSE24585 | Down | -0.0178777603 |
| GSE37065 | Down | -0.1480840014 |
| GSE28863_A1 | Up | 0.0011370270 |
| GSE28863_A2 | Up | 0.4775183870 |
| GSE28863_A3 | Down | -0.6600551101 |
| GSE28863_A4 | Down | -0.1578340851 |
| GSE48662 | Down | -0.1524748649 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031565 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048620 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
