HCSGD entry for DMD

1. General information

Official gene symbolDMD
Entrez ID1756
Gene full namedystrophin
Other gene symbolsBMD CMD3B DXS142 DXS164 DXS206 DXS230 DXS239 DXS268 DXS269 DXS270 DXS272
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001954Positive regulation of cell-matrix adhesionIEAbiological_process
GO:0002027Regulation of heart rateIEA IMPbiological_process
GO:0002162Dystroglycan bindingIPImolecular_function
GO:0003779Actin bindingIDA IEA TASmolecular_function
GO:0005200Structural constituent of cytoskeletonTASmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA TAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0007517Muscle organ developmentNASbiological_process
GO:0007519Skeletal muscle tissue developmentIEAbiological_process
GO:0008065Establishment of blood-nerve barrierIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008307Structural constituent of muscleIDA TASmolecular_function
GO:0009986Cell surfaceIDAcellular_component
GO:0010880Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumISSbiological_process
GO:0010881Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionIEA ISSbiological_process
GO:0010976Positive regulation of neuron projection developmentIMPbiological_process
GO:0014809Regulation of skeletal muscle contraction by regulation of release of sequestered calcium ionIEA ISSbiological_process
GO:0014819Regulation of skeletal muscle contractionISSbiological_process
GO:0014904Myotube cell developmentIEAbiological_process
GO:0015629Actin cytoskeletonTAScellular_component
GO:0016010Dystrophin-associated glycoprotein complexIDA IEA NAS TAScellular_component
GO:0016013Syntrophin complexTAScellular_component
GO:0016328Lateral plasma membraneTAScellular_component
GO:0017022Myosin bindingIDAmolecular_function
GO:0017166Vinculin bindingIPImolecular_function
GO:0021629Olfactory nerve structural organizationIEAbiological_process
GO:0030018Z discIEAcellular_component
GO:0030049Muscle filament slidingTASbiological_process
GO:0030055Cell-substrate junctionIEAcellular_component
GO:0030175FilopodiumIDAcellular_component
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0033137Negative regulation of peptidyl-serine phosphorylationIEA ISSbiological_process
GO:0034613Cellular protein localizationIEA IMPbiological_process
GO:0042383SarcolemmaIDA IEAcellular_component
GO:0043034CostamereIDAcellular_component
GO:0043043Peptide biosynthetic processIDAbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0043623Cellular protein complex assemblyIEA ISSbiological_process
GO:0044306Neuron projection terminusIEAcellular_component
GO:0044458Motile cilium assemblyTASbiological_process
GO:0045121Membrane raftIEA TAScellular_component
GO:0045202SynapseIEAcellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0045213Neurotransmitter receptor metabolic processIEAbiological_process
GO:0045666Positive regulation of neuron differentiationIMPbiological_process
GO:0046716Muscle cell cellular homeostasisIEAbiological_process
GO:0048747Muscle fiber developmentIEAbiological_process
GO:0050998Nitric-oxide synthase bindingIEA ISSmolecular_function
GO:0051647Nucleus localizationIEAbiological_process
GO:0060048Cardiac muscle contractionIMPbiological_process
GO:0060314Regulation of ryanodine-sensitive calcium-release channel activityIEA ISSbiological_process
GO:0060857Establishment of glial blood-brain barrierIEAbiological_process
GO:0086001Cardiac muscle cell action potentialIEA ISSbiological_process
GO:0090287Regulation of cellular response to growth factor stimulusIMPbiological_process
GO:1901385Regulation of voltage-gated calcium channel activityIEA ISSbiological_process
GO:1902083Negative regulation of peptidyl-cysteine S-nitrosylationIEA ISSbiological_process
GO:2000651Positive regulation of sodium ion transmembrane transporter activityIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.54108455230.17805411650.99999024730.8159391365

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3224791004
GSE13712_SHEARUp0.0468054726
GSE13712_STATICUp0.2233313910
GSE19018Down-0.3299058472
GSE19899_A1Up0.1915162003
GSE19899_A2Up0.1248173337
PubMed_21979375_A1Down-0.4480014352
PubMed_21979375_A2Up0.1190833257
GSE35957Up0.6186542379
GSE36640Up0.7865605353
GSE54402Down-0.4563178700
GSE9593Up0.1503161844
GSE43922Down-0.0977804361
GSE24585Down-0.5208963570
GSE37065Down-0.2571028369
GSE28863_A1Down-0.2172609817
GSE28863_A2Up0.0033706532
GSE28863_A3Up0.0456445771
GSE28863_A4Up0.0800675012
GSE48662Up0.1888826258

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT005060MicroarrayFunctional MTI (Weak)17699775
hsa-miR-31-5pMIMAT0000089MIRT005456Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21212803
hsa-miR-155-5pMIMAT0000646MIRT020813ProteomicsFunctional MTI (Weak)18668040
hsa-miR-21-5pMIMAT0000076MIRT030888MicroarrayFunctional MTI (Weak)18591254
hsa-miR-16-5pMIMAT0000069MIRT031761ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

17617801The progression of Duchenne muscular dystrophy (DMD) is, in part, due to satellite cell senescence driven by high replicative pressure as these muscle stem cells repeatedly divide and fuse to damaged muscle fibers
17617801These findings indicate that satellite cells undergo telomere erosion, which may contribute to the inability of these cells to perpetually repair DMD muscle
7251683Fibroblast cultures from patients with Duchenne muscular dystrophy (DMD) were used as additional controls, as premature aging is not associated with this genetic disorder
7251683Our results demonstrate that there is no difference in the limits of the in vitro lifespan for either the MyD or DMD fibroblast strains compared to the controls
7251683The only observable difference was that the pooled age-matched controls and MyD cultures had a shorter in vitro lifespan than the DMD group and their pooled controls, a finding expected because of the age of the patients in each group
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