HCSGD entry for E2F3
1. General information
| Official gene symbol | E2F3 |
|---|---|
| Entrez ID | 1871 |
| Gene full name | E2F transcription factor 3 |
| Other gene symbols | E2F-3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000085 | Mitotic G2 phase | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0001047 | Core promoter binding | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1845667376 | 0.3963289845 | 0.8394645067 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2151888945 |
| GSE13712_SHEAR | Up | 0.0415033818 |
| GSE13712_STATIC | Down | -0.1718038643 |
| GSE19018 | Down | -1.0739075393 |
| GSE19899_A1 | Down | -0.2273484962 |
| GSE19899_A2 | Up | 0.5559081102 |
| PubMed_21979375_A1 | Up | 0.1135096632 |
| PubMed_21979375_A2 | Up | 0.6888477566 |
| GSE35957 | Up | 0.1720329702 |
| GSE36640 | Down | -0.2470697362 |
| GSE54402 | Up | 0.3116510394 |
| GSE9593 | Up | 0.0887987566 |
| GSE43922 | Up | 0.1529243892 |
| GSE24585 | Up | 0.0428750942 |
| GSE37065 | Down | -0.0927270510 |
| GSE28863_A1 | Up | 0.4595729651 |
| GSE28863_A2 | Up | 0.6597739624 |
| GSE28863_A3 | Down | -0.2770326099 |
| GSE28863_A4 | Down | -0.2417875833 |
| GSE48662 | Down | -0.1794288446 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-195-5p | MIMAT0000461 | MIRT000223 | Immunohistochemistry//Luciferase reporter assay//Northern blot//qRT-PCR//Western blot//Reporter assay;Western blot;qRT-PCR;Other | Functional MTI | 19441017 |
| hsa-miR-195-5p | MIMAT0000461 | MIRT000223 | Luciferase reporter assay//Western blot | Functional MTI | 22217655 |
| hsa-miR-34c-5p | MIMAT0000686 | MIRT000760 | Luciferase reporter assay | Functional MTI | 19461653 |
| hsa-miR-34c-5p | MIMAT0000686 | MIRT000760 | Luciferase reporter assay//Western blot | Functional MTI | 18768788 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT006298 | Flow//Luciferase reporter assay//Western blot | Functional MTI | 22139708 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT006298 | Flow//Luciferase reporter assay//Western blot | Functional MTI | 22144583 |
| hsa-miR-203a | MIMAT0000264 | MIRT006268 | Luciferase reporter assay | Functional MTI | 22354972 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT001756 | Luciferase reporter assay//Western blot | Functional MTI | 17252019 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT001756 | Luciferase reporter assay | Functional MTI | 19461653 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT001756 | Luciferase reporter assay//Western blot//Microarray | Functional MTI | 17914404 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT001756 | Immunoblot//Immunohistochemistry//qRT-PCR | Functional MTI (Weak) | 17875987 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT001756 | Luciferase reporter assay//Western blot//Western blot;Other | Functional MTI | 17297439 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT001756 | Immunoprecipitaion//Luciferase reporter assay//qRT-PCR | Functional MTI | 20889924 |
| hsa-miR-210-3p | MIMAT0000267 | MIRT003184 | immunoprecipitaion//qRT-PCR | Functional MTI (Weak) | 19826008 |
| hsa-miR-210-3p | MIMAT0000267 | MIRT003184 | Luciferase reporter assay | Functional MTI | 21465485 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT003734 | Luciferase reporter assay | Functional MTI | 18810376 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT003734 | Luciferase reporter assay | Functional MTI | 19013014 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT005503 | Immunohistochemistry//Luciferase reporter assay//Northern blot//qRT-PCR//Western blot//Reporter assay;Other | Functional MTI | 20549700 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT005503 | Immunohistochemistry//qRT-PCR//Western blot | Functional MTI | 22523546 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT005849 | Luciferase reporter assay | Non-Functional MTI | 21283765 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT005855 | Luciferase reporter assay | Non-Functional MTI | 21283765 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT005863 | Luciferase reporter assay | Non-Functional MTI | 21283765 |
| hsa-miR-141-3p | MIMAT0000432 | MIRT021649 | Western blot | Functional MTI | 20053927 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT024159 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027334 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028350 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030551 | qRT-PCR;Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045547 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047838 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051187 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051918 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | 1 | hsa-miR-34a | {Western blot} | {overexpression by miRNA precursor transfection} | 17297439 | |
| hsa-miR-34a-5p | MIMAT0000255 | NA | hsa-miR-34a | {Western blot} | {overexpression by miRNA precursor transfection} | 18834855 | |
| hsa-miR-195-5p | MIMAT0000461 | 1 | hsa-miR-195 | {Western blot} | {overexpression} | 19441017 | |
| hsa-miR-125b-5p | MIMAT0000423 | 1 | hsa-miR-125b | {Western blot} | {overexpression by miRNA mimics tranfection} | 20549700 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26514209 | Syndecan-1 expression diminished, whereas stem cell markers such as SOX2, NANOG, OCT4, and E2F3 increased |
| 25684390 | Furthermore, in silico analysis identified four possible miR-433 target genes associated with cellular senescence: cyclin-dependent kinase 6 (CDK6), MAPK14, E2F3, and CDKN2A |
| 24211326 | Tumor-suppressive microRNA-449a induces growth arrest and senescence by targeting E2F3 in human lung cancer cells |
| 24211326 | Further studies revealed that E2F3 was a direct target of miR-449a in lung cancer cells |
| 18076574 | Polycomb complexes regulate cellular senescence by repression of ARF in cooperation with E2F3 |
| 11640890 | Expression by recombinant adenovirus of E2F1, E2F2, E2F3, cyclin E/cdk2, and Mdm2 individually resulted in DNA synthesis in 10-30% of cells |
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