HCSGD entry for EDN2

1. General information

Official gene symbolEDN2
Entrez ID1907
Gene full nameendothelin 2
Other gene symbolsET2 PPET2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001516Prostaglandin biosynthetic processIDAbiological_process
GO:0002690Positive regulation of leukocyte chemotaxisIDAbiological_process
GO:0003058Hormonal regulation of the force of heart contractionTASbiological_process
GO:0003099Positive regulation of the force of heart contraction by chemical signalTASbiological_process
GO:0003100Regulation of systemic arterial blood pressure by endothelinIDAbiological_process
GO:0005179Hormone activityIDAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0007166Cell surface receptor signaling pathwayICbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIDAbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0010460Positive regulation of heart rateIDAbiological_process
GO:0014824Artery smooth muscle contractionIDAbiological_process
GO:0014826Vein smooth muscle contractionIDAbiological_process
GO:0019221Cytokine-mediated signaling pathwayIDAbiological_process
GO:0019229Regulation of vasoconstrictionIEAbiological_process
GO:0019722Calcium-mediated signalingIDAbiological_process
GO:0030593Neutrophil chemotaxisIDAbiological_process
GO:0042116Macrophage activationIDAbiological_process
GO:0042310VasoconstrictionIDAbiological_process
GO:0045987Positive regulation of smooth muscle contractionIEAbiological_process
GO:0048016Inositol phosphate-mediated signalingIDAbiological_process
GO:0048246Macrophage chemotaxisIDAbiological_process
GO:0060585Positive regulation of prostaglandin-endoperoxide synthase activityIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31774887730.94058689260.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1288169857
GSE13712_SHEARDown-0.1423522423
GSE13712_STATICUp0.0455375284
GSE19018Up0.1404852178
GSE19899_A1Up0.0572565032
GSE19899_A2Up0.1459387977
PubMed_21979375_A1Up0.2111229070
PubMed_21979375_A2Up0.0620383350
GSE35957Up0.0349618936
GSE36640Down-0.0702040590
GSE54402Down-0.0431363112
GSE9593Up0.1590320049
GSE43922Up0.0610150077
GSE24585Down-0.0509855827
GSE37065Up0.1189053882
GSE28863_A1Down-0.0534638831
GSE28863_A2Up0.0078723509
GSE28863_A3Up0.2839144624
GSE28863_A4Up0.1936498598
GSE48662Up0.0093939336

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT030221MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.