HCSGD entry for EIF2B1

1. General information

Official gene symbolEIF2B1
Entrez ID1967
Gene full nameeukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
Other gene symbolsEIF2B EIF2BA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003743Translation initiation factor activityIDA IEAmolecular_function
GO:0005085Guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005851Eukaryotic translation initiation factor 2B complexIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006412TranslationTASbiological_process
GO:0006413Translational initiationIDA TASbiological_process
GO:0006446Regulation of translational initiationIBAbiological_process
GO:0009408Response to heatISS TASbiological_process
GO:0009749Response to glucoseISSbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0014003Oligodendrocyte developmentIMPbiological_process
GO:0016020MembraneIDAcellular_component
GO:0019003GDP bindingIEAmolecular_function
GO:0019509L-methionine salvage from methylthioadenosineIBAbiological_process
GO:0030234Enzyme regulator activityIEAmolecular_function
GO:0032057Negative regulation of translational initiation in response to stressIEAbiological_process
GO:0043087Regulation of GTPase activityIDAbiological_process
GO:0043434Response to peptide hormoneISSbiological_process
GO:0044237Cellular metabolic processIEAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0046523S-methyl-5-thioribose-1-phosphate isomerase activityIBAmolecular_function
GO:0051716Cellular response to stimulusIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89253422740.17490455530.99999024730.8092217964

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2941748154
GSE13712_SHEARDown-0.0953564864
GSE13712_STATICDown-0.0043269703
GSE19018Down-0.4511624662
GSE19899_A1Down-0.0817061040
GSE19899_A2Up0.0507929403
PubMed_21979375_A1Down-0.4503157032
PubMed_21979375_A2Down-0.1799006195
GSE35957Down-0.2266023728
GSE36640Down-0.2329037847
GSE54402Down-0.0451198252
GSE9593Down-0.0243097529
GSE43922Down-0.0178949863
GSE24585Up0.1305624861
GSE37065Down-0.1926378573
GSE28863_A1Up0.1773197721
GSE28863_A2Up0.0132232971
GSE28863_A3Down-0.4543263793
GSE28863_A4Up0.1329975075
GSE48662Down-0.3802821798

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-5pMIMAT0000087MIRT028525ProteomicsFunctional MTI (Weak)18668040
hsa-miR-26b-5pMIMAT0000083MIRT029246MicroarrayFunctional MTI (Weak)19088304
hsa-miR-1228-3pMIMAT0005583MIRT036393CLASHFunctional MTI (Weak)23622248
hsa-miR-30b-5pMIMAT0000420MIRT046139CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.