HCSGD entry for EIF4G2
1. General information
| Official gene symbol | EIF4G2 |
|---|---|
| Entrez ID | 1982 |
| Gene full name | eukaryotic translation initiation factor 4 gamma, 2 |
| Other gene symbols | AAG1 DAP5 NAT1 P97 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0003743 | Translation initiation factor activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006446 | Regulation of translational initiation | IDA | biological_process |
| GO:0007050 | Cell cycle arrest | TAS | biological_process |
| GO:0008135 | Translation factor activity, nucleic acid binding | IDA | molecular_function |
| GO:0008219 | Cell death | TAS | biological_process |
| GO:0016281 | Eukaryotic translation initiation factor 4F complex | IDA | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9758610653 | 0.1296055507 | 0.9999902473 | 0.6930923202 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0250117760 |
| GSE13712_SHEAR | Up | 0.1103951271 |
| GSE13712_STATIC | Down | -0.0446968778 |
| GSE19018 | Down | -0.1155188587 |
| GSE19899_A1 | Down | -0.1374827396 |
| GSE19899_A2 | Down | -0.1636530804 |
| PubMed_21979375_A1 | Down | -0.5119773378 |
| PubMed_21979375_A2 | Down | -0.0862312650 |
| GSE35957 | Up | 0.2126734869 |
| GSE36640 | Down | -0.0451638882 |
| GSE54402 | Down | -0.1316663798 |
| GSE9593 | Down | -0.0622207106 |
| GSE43922 | Down | -0.2176017450 |
| GSE24585 | Up | 0.0844654824 |
| GSE37065 | Up | 0.0076720803 |
| GSE28863_A1 | Down | -0.1011314523 |
| GSE28863_A2 | Down | -0.1809695965 |
| GSE28863_A3 | Down | -0.3057652387 |
| GSE28863_A4 | Down | -0.0326150680 |
| GSE48662 | Down | -0.5557642710 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020531 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032243 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036335 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-151a-5p | MIMAT0004697 | MIRT038198 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-421 | MIMAT0003339 | MIRT039371 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042054 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-424-5p | MIMAT0001341 | MIRT042446 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043364 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044940 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106a-5p | MIMAT0000103 | MIRT048353 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048891 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049744 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050322 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050617 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT051028 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-let-7d-5p | MIMAT0000065 | NA | hsa-let-7d | 19939273 | |||
| hsa-let-7g-5p | MIMAT0000414 | NA | hsa-let-7g | 19939273 | |||
| hsa-let-7i-5p | MIMAT0000415 | NA | hsa-let-7i | 19939273 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
