HCSGD entry for EPHA3

1. General information

Official gene symbolEPHA3
Entrez ID2042
Gene full nameEPH receptor A3
Other gene symbolsEK4 ETK ETK1 HEK HEK4 TYRO4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005003Ephrin receptor activityIEAmolecular_function
GO:0005004GPI-linked ephrin receptor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005769Early endosomeIDAcellular_component
GO:0005887Integral component of plasma membraneIDA IEAcellular_component
GO:0007155Cell adhesionIEAbiological_process
GO:0010717Regulation of epithelial to mesenchymal transitionISSbiological_process
GO:0010976Positive regulation of neuron projection developmentIMPbiological_process
GO:0016477Cell migrationISSbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0032319Regulation of Rho GTPase activityIDAbiological_process
GO:0032956Regulation of actin cytoskeleton organizationIDAbiological_process
GO:0048013Ephrin receptor signaling pathwayIDAbiological_process
GO:0051893Regulation of focal adhesion assemblyIDAbiological_process
GO:0070507Regulation of microtubule cytoskeleton organizationIDAbiological_process
GO:0071300Cellular response to retinoic acidIMPbiological_process
GO:0097155Fasciculation of sensory neuron axonISSbiological_process
GO:0097156Fasciculation of motor neuron axonISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95692853990.08816823450.99999024730.5631342150

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0099022573
GSE13712_SHEARUp0.0407541768
GSE13712_STATICDown-0.0961004938
GSE19018Down-0.0376773779
GSE19899_A1Up0.0391260855
GSE19899_A2Down-0.1715702537
PubMed_21979375_A1Up0.1505041345
PubMed_21979375_A2Down-0.0331211579
GSE35957Down-0.2862254182
GSE36640Up0.0050913438
GSE54402Down-0.2718555917
GSE9593Up0.2139677140
GSE43922Up0.0050151692
GSE24585Down-0.4076400328
GSE37065Down-0.9005477163
GSE28863_A1Up0.0479609587
GSE28863_A2Down-0.3416640592
GSE28863_A3Up0.0239883961
GSE28863_A4Down-0.0551874557
GSE48662Down-0.2863811733

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23324396A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3
23324396One such candidate is the EPHA3 receptor tyrosine kinase, a gene commonly mutated in human cancer
23324396We demonstrate that selected intracellular EPHA3 tumor-associated point mutations decrease receptor expression level and/or receptor tyrosine kinase (RTK) activity
23324396Our study therefore describes a new strategy to mine for novel candidate tumor suppressors and provides compelling evidence that EPHA3 mutations may promote tumorigenesis only when key senescence-inducing pathways have been inactivated
20045429In the present study, we compared the bioimpact of two chemically modified fullerene derivatives, hexa carboxyl fullerene adduct (Hexa-C(60)) and tris carboxyl fullerene adduct (tris-C(60)) to pristine fullerene C(60) encapsulated with gamma (gamma)-cyclodextrin C(60) (CD-C(60)), using human cutaneous epithelial cells (HEK) to simulate possible applications and occupational dermal exposure route
20027224Interestingly, genes that showed the most significant link include those that mediate various signaling pathways implicated in colorectal tumorigenesis, such as BMP3 and BMP6 (BMP signaling), EPHA3, KIT, and FLT1 (receptor tyrosine kinases) and SMO (Hedgehog signaling)
19133275Furthermore, in HEK (human embryonic kidney)-293 (T) cells, an interaction of the overexpressed recombinant EWS-yellow fluorescent protein fusion protein with microtubules, leading to their stabilization and cell cycle arrest, was demonstrated
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