HCSGD entry for ERCC1
1. General information
| Official gene symbol | ERCC1 |
|---|---|
| Entrez ID | 2067 |
| Gene full name | excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) |
| Other gene symbols | COFS4 RAD10 UV20 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000014 | Single-stranded DNA endodeoxyribonuclease activity | IDA | molecular_function |
| GO:0000109 | Nucleotide-excision repair complex | IDA | cellular_component |
| GO:0000718 | Nucleotide-excision repair, DNA damage removal | TAS | biological_process |
| GO:0000720 | Pyrimidine dimer repair by nucleotide-excision repair | IEA | biological_process |
| GO:0000737 | DNA catabolic process, endonucleolytic | IDA | biological_process |
| GO:0000784 | Nuclear chromosome, telomeric region | IDA | cellular_component |
| GO:0001094 | TFIID-class transcription factor binding | IEA | molecular_function |
| GO:0001302 | Replicative cell aging | IEA | biological_process |
| GO:0003684 | Damaged DNA binding | IDA IEA | molecular_function |
| GO:0003697 | Single-stranded DNA binding | IDA | molecular_function |
| GO:0004519 | Endonuclease activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005669 | Transcription factor TFIID complex | IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006281 | DNA repair | IEA TAS | biological_process |
| GO:0006283 | Transcription-coupled nucleotide-excision repair | TAS | biological_process |
| GO:0006289 | Nucleotide-excision repair | IDA IGI TAS | biological_process |
| GO:0006295 | Nucleotide-excision repair, DNA incision, 3'-to lesion | IMP | biological_process |
| GO:0006296 | Nucleotide-excision repair, DNA incision, 5'-to lesion | IMP | biological_process |
| GO:0006302 | Double-strand break repair | IEA | biological_process |
| GO:0006310 | DNA recombination | IGI | biological_process |
| GO:0006312 | Mitotic recombination | IMP | biological_process |
| GO:0006949 | Syncytium formation | IEA | biological_process |
| GO:0006979 | Response to oxidative stress | IMP | biological_process |
| GO:0007281 | Germ cell development | IEA | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0007584 | Response to nutrient | IEA | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0008584 | Male gonad development | IEA | biological_process |
| GO:0009650 | UV protection | IEA | biological_process |
| GO:0009744 | Response to sucrose | IEA | biological_process |
| GO:0010165 | Response to X-ray | IEA | biological_process |
| GO:0010259 | Multicellular organismal aging | IEA | biological_process |
| GO:0017025 | TBP-class protein binding | IEA | molecular_function |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0032205 | Negative regulation of telomere maintenance | IMP | biological_process |
| GO:0035166 | Post-embryonic hemopoiesis | IEA | biological_process |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0043566 | Structure-specific DNA binding | IDA | molecular_function |
| GO:0045190 | Isotype switching | IEA | biological_process |
| GO:0048477 | Oogenesis | IEA | biological_process |
| GO:0048568 | Embryonic organ development | IEA | biological_process |
| GO:0051276 | Chromosome organization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0066588693 | 0.8874146385 | 0.2142641809 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0497201013 |
| GSE13712_SHEAR | Down | -0.2079857879 |
| GSE13712_STATIC | Down | -0.0324592295 |
| GSE19018 | Down | -0.0374237969 |
| GSE19899_A1 | Up | 1.6803362824 |
| GSE19899_A2 | Up | 1.2534389262 |
| PubMed_21979375_A1 | Up | 2.6782655852 |
| PubMed_21979375_A2 | Up | 1.5389752848 |
| GSE35957 | Down | -0.1017654603 |
| GSE36640 | Down | -0.0588995938 |
| GSE54402 | Up | 1.3851495762 |
| GSE9593 | Up | 0.3097687345 |
| GSE43922 | Up | 0.8077932219 |
| GSE24585 | Up | 0.3512383038 |
| GSE37065 | Down | -0.0567732658 |
| GSE28863_A1 | Down | -0.0771028313 |
| GSE28863_A2 | Down | -0.1810375519 |
| GSE28863_A3 | Down | -0.4897509820 |
| GSE28863_A4 | Up | 0.1101754295 |
| GSE48662 | Down | -0.0800290970 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-296-3p | MIMAT0004679 | MIRT038492 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052171 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 8 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26464516 | To test our hypothesis, we combined experiments in mice with genomic instability resulting from the defective nucleotide excision repair gene ERCC1 (Ercc1(d/-) mice), human VSMC cultures and population genome-wide association studies (GWAS) |
| 26102775 | DESIGN AND METHOD: Studies were performed in male and female Ercc1d/- mice and their wild type controls (Ercc1+/+) at the age of 12 or 18 weeks before and after treatment with losartan |
| 26102775 | The ReninSense 680 probe showed increased intrarenal renin activity in Ercc1d/- mice versus Ercc1+/+ mice, both at 12 and 18 weeks of age, while PRC in these mice tended to be lower compared to Ercc1+/+ mice |
| 26102775 | Renin was higher in male than female mice, both in the kidney and in plasma, and losartan increased kidney and plasma renin in both Ercc1d/- and Ercc1+/+ mice |
| 25754370 | Periodic drug administration extended healthspan in Ercc1(-/) mice, delaying age-related symptoms and pathology, osteoporosis, and loss of intervertebral disk proteoglycans |
| 24964749 | Involvement of ERCC1 in the pathogenesis of osteoarthritis through the modulation of apoptosis and cellular senescence |
| 24964749 | In this study we investigated the function of ERCC1 in chondrocytes and its association with the pathophysiology of OA |
| 24964749 | ERCC1 expression in normal and osteoarthritic cartilage was assessed, as were changes in ERCC1 expression in chondrocytes under catabolic stress |
| 24964749 | Inhibiting ERCC1 in chondrocytes under interleukin-1beta stimulation using small interfering RNA (siRNA) was also evaluated |
| 24964749 | Finally, cellular senescence and apoptosis were examined in relation to ERCC1 function |
| 24964749 | ERCC1 expression was decreased in OA cartilage and increased within 4 h of exposure to interleukin (IL)-1beta, but decreased after 12 h |
| 24964749 | The inhibition of ERCC1 by siRNA increased the expression of matrix metallopeptidase 13 and decreased collagen type II |
| 24964749 | ERCC1 inhibition also increased the number of apoptotic and senescent cells |
| 23852002 | XFE progeroid syndrome, a disease of accelerated aging caused by deficiency in the DNA repair endonuclease XPF-ERCC1, is modeled by Ercc1 knockout and hypomorphic mice |
| 23852002 | We compared microRNA (miRNA) expression in Ercc1-/- primary mouse embryonic fibroblasts (MEFs) and wild-type (WT) MEFs in different growth conditions to identify miRNAs that drive cellular senescence |
| 23852002 | Microarray analysis showed three differentially expressed miRNAs in passage 7 (P7) Ercc1-/- MEFs grown at 20% O2 compared to Ercc1-/- MEFs grown at 3% O2 |
| 23852002 | Thirty-six differentially expressed miRNAs were identified in Ercc1-/- MEFs at P7 compared to early passage (P3) in 3% O2 |
| 23281008 | Herein, we used progeroid ERCC1-XPF-deficient mice, including Ercc1-null (Ercc1(-/-)) and hypomorphic (Ercc1(-/Delta)) mice, to investigate the mechanism by which DNA damage leads to accelerated bone aging |
| 23281008 | Compared to their wild-type littermates, both Ercc1(-/-) and Ercc1(-/Delta) mice display severe, progressive osteoporosis caused by reduced bone formation and enhanced osteoclastogenesis |
| 23281008 | ERCC1 deficiency leads to atrophy of osteoblastic progenitors in the bone marrow stromal cell (BMSC) population |
| 23281008 | Furthermore, we found that the transcription factor NF-kappaB is activated in osteoblastic and osteoclastic cells of the Ercc1 mutant mice |
| 22705887 | METHODS AND RESULTS: In mice with genomic instability resulting from the defective nucleotide excision repair genes ERCC1 and XPD (Ercc1(d/-) and Xpd(TTD) mice), we explored age-dependent vascular function compared with that in wild-type mice |
| 18083760 | Therefore, we summarize and discuss here that (i) systemic administration of anti-cancer chemotherapeutics, in many cases DNA cross-linking drugs, induces premature progeroid frailty in long-term survivors; (ii) that ICL-inducing 8-methoxy-psoralen/UVA phototherapy leads to signs of premature skin aging as prominent long-term side effect and (iii) that mutated factors involved in ICL repair like ERCC1/XPF, the Fanconi anaemia proteins, WRN and SNEV lead to reduced replicative life span in vitro and segmental progeroid syndromes in vivo |
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