HCSGD entry for MECOM

1. General information

Official gene symbol	MECOM
Entrez ID	2122
Gene full name	MDS1 and EVI1 complex locus
Other gene symbols	AML1-EVI-1 EVI1 MDS1 MDS1-EVI1 PRDM3
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0000118	Histone deacetylase complex	IDA	cellular_component
GO:0001701	In utero embryonic development	IEA	biological_process
GO:0001780	Neutrophil homeostasis	IEA	biological_process
GO:0003676	Nucleic acid binding	IEA	molecular_function
GO:0003677	DNA binding	IEA ISS	molecular_function
GO:0003700	Sequence-specific DNA binding transcription factor activity	IDA TAS	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005634	Nucleus	IDA	cellular_component
GO:0006351	Transcription, DNA-templated	IEA	biological_process
GO:0006355	Regulation of transcription, DNA-templated	TAS	biological_process
GO:0006915	Apoptotic process	IEA	biological_process
GO:0006954	Inflammatory response	IEA	biological_process
GO:0009617	Response to bacterium	IEA	biological_process
GO:0009791	Post-embryonic development	IEA	biological_process
GO:0016607	Nuclear speck	IDA	cellular_component
GO:0030154	Cell differentiation	IEA	biological_process
GO:0030512	Negative regulation of transforming growth factor beta receptor signaling pathway	IDA	biological_process
GO:0030900	Forebrain development	IEA	biological_process
GO:0035115	Embryonic forelimb morphogenesis	IEA	biological_process
GO:0035116	Embryonic hindlimb morphogenesis	IEA	biological_process
GO:0042127	Regulation of cell proliferation	IEA	biological_process
GO:0042803	Protein homodimerization activity	IDA	molecular_function
GO:0043069	Negative regulation of programmed cell death	IMP	biological_process
GO:0045892	Negative regulation of transcription, DNA-templated	IDA	biological_process
GO:0045893	Positive regulation of transcription, DNA-templated	IDA	biological_process
GO:0045944	Positive regulation of transcription from RNA polymerase II promoter	IEA	biological_process
GO:0046329	Negative regulation of JNK cascade	IMP	biological_process
GO:0046872	Metal ion binding	IEA	molecular_function
GO:0051726	Regulation of cell cycle	IDA	biological_process
GO:0060039	Pericardium development	IEA	biological_process
GO:0071425	Hematopoietic stem cell proliferation	ISS	biological_process
GO:0072001	Renal system development	IEA	biological_process
GO:2001141	Regulation of RNA biosynthetic process	TAS	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.8908199802	0.2913315755	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.0062167532
GSE13712_SHEAR	Up	0.0376413410
GSE13712_STATIC	Down	-0.0632800444
GSE19018	Up	0.0299249791
GSE19899_A1	Down	-0.1952262867
GSE19899_A2	Down	-0.3578143441
PubMed_21979375_A1	Down	-0.2230245972
PubMed_21979375_A2	Down	-0.1777197276
GSE35957	Up	0.3277924084
GSE36640	Down	-0.5180540585
GSE54402	Down	-0.2693051170
GSE9593	Down	-0.0454398494
GSE43922	Up	0.0093804070
GSE24585	Down	-0.1509653341
GSE37065	Up	0.4172893670
GSE28863_A1	Up	0.0378151935
GSE28863_A2	Up	0.1570278796
GSE28863_A3	Down	-0.0334812373
GSE28863_A4	Up	0.0042059811
GSE48662	Up	0.0379300220

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results