HCSGD entry for F2R

1. General information

Official gene symbolF2R
Entrez ID2149
Gene full namecoagulation factor II (thrombin) receptor
Other gene symbolsCF2R HTR PAR-1 PAR1 TR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000186Activation of MAPKK activityISSbiological_process
GO:0001965G-protein alpha-subunit bindingISSmolecular_function
GO:0002248Connective tissue replacement involved in inflammatory response wound healingIDAbiological_process
GO:0003105Negative regulation of glomerular filtrationISSbiological_process
GO:0004930G-protein coupled receptor activityISS TASmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005794Golgi apparatusTAScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0005901CaveolaIDAcellular_component
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0006954Inflammatory responseISSbiological_process
GO:0007186G-protein coupled receptor signaling pathwayISSbiological_process
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationISSbiological_process
GO:0007205Protein kinase C-activating G-protein coupled receptor signaling pathwayISSbiological_process
GO:0007260Tyrosine phosphorylation of STAT proteinIDAbiological_process
GO:0007262STAT protein import into nucleusIDAbiological_process
GO:0007529Establishment of synaptic specificity at neuromuscular junctionISSbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008284Positive regulation of cell proliferationISSbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0009611Response to woundingIDAbiological_process
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingISSbiological_process
GO:0015057Thrombin receptor activityIDAmolecular_function
GO:0030168Platelet activationIDA TASbiological_process
GO:0030193Regulation of blood coagulationIDAbiological_process
GO:0030194Positive regulation of blood coagulationIDAbiological_process
GO:0030335Positive regulation of cell migrationIMPbiological_process
GO:0031094Platelet dense tubular networkIDAcellular_component
GO:0031594Neuromuscular junctionISScellular_component
GO:0031681G-protein beta-subunit bindingISSmolecular_function
GO:0032496Response to lipopolysaccharideISSbiological_process
GO:0032651Regulation of interleukin-1 beta productionISSbiological_process
GO:0032967Positive regulation of collagen biosynthetic processIDAbiological_process
GO:0035025Positive regulation of Rho protein signal transductionISSbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEPbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0043410Positive regulation of MAPK cascadeIDAbiological_process
GO:0043524Negative regulation of neuron apoptotic processISSbiological_process
GO:0045211Postsynaptic membraneISScellular_component
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045907Positive regulation of vasoconstrictionISSbiological_process
GO:0045987Positive regulation of smooth muscle contractionISSbiological_process
GO:0046427Positive regulation of JAK-STAT cascadeIDAbiological_process
GO:0048873Homeostasis of number of cells within a tissueISSbiological_process
GO:0051209Release of sequestered calcium ion into cytosolISSbiological_process
GO:0051281Positive regulation of release of sequestered calcium ion into cytosolIDAbiological_process
GO:0051482Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayISSbiological_process
GO:0051928Positive regulation of calcium ion transportISSbiological_process
GO:0051930Regulation of sensory perception of painISSbiological_process
GO:0060155Platelet dense granule organizationICbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:1900134Negative regulation of renin secretion into blood streamISSbiological_process
GO:2000484Positive regulation of interleukin-8 secretionIDAbiological_process
GO:2000778Positive regulation of interleukin-6 secretionIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.23477485280.06504749820.91765798930.4816076512

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2549235490
GSE13712_SHEARUp0.4056052332
GSE13712_STATICUp0.3530679697
GSE19018Down-0.0271567853
GSE19899_A1Up0.1703669452
GSE19899_A2Up0.5923762077
PubMed_21979375_A1Down-0.4731565985
PubMed_21979375_A2Up0.2256753932
GSE35957Down-0.1745448854
GSE36640Up0.0326891578
GSE54402Down-0.0252778147
GSE9593Up0.7900244900
GSE43922Up0.0074791949
GSE24585Down-0.6881635018
GSE37065Down-0.5101516615
GSE28863_A1Down-0.6711943278
GSE28863_A2Down-0.3231072532
GSE28863_A3Down-0.0872036327
GSE28863_A4Down-0.1728685866
GSE48662Down-0.5438172758

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

StreptokinaseDB00086 BTD00028 | BIOD00028
SR-123781ADB05361 -
SCH-530348DB05692 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-877-3pMIMAT0004950MIRT037083CLASHFunctional MTI (Weak)23622248
hsa-let-7a-5pMIMAT0000062MIRT052570CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.