HCSGD entry for ACSL3
1. General information
| Official gene symbol | ACSL3 |
|---|---|
| Entrez ID | 2181 |
| Gene full name | acyl-CoA synthetase long-chain family member 3 |
| Other gene symbols | ACS3 FACL3 PRO2194 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004467 | Long-chain fatty acid-CoA ligase activity | IEA IMP | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005741 | Mitochondrial outer membrane | IEA | cellular_component |
| GO:0005778 | Peroxisomal membrane | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005811 | Lipid particle | IDA | cellular_component |
| GO:0006633 | Fatty acid biosynthetic process | IEA | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0007584 | Response to nutrient | IEA | biological_process |
| GO:0014070 | Response to organic cyclic compound | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0034379 | Very-low-density lipoprotein particle assembly | IMP | biological_process |
| GO:0042998 | Positive regulation of Golgi to plasma membrane protein transport | IMP | biological_process |
| GO:0044539 | Long-chain fatty acid import | IDA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0051047 | Positive regulation of secretion | IMP | biological_process |
| GO:2001247 | Positive regulation of phosphatidylcholine biosynthetic process | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4391520269 | 0.1664862543 | 0.9999902473 | 0.7890918452 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3285493722 |
| GSE13712_SHEAR | Down | -0.0094461599 |
| GSE13712_STATIC | Up | 0.0538664094 |
| GSE19018 | Down | -0.1382956021 |
| GSE19899_A1 | Down | -0.2442329265 |
| GSE19899_A2 | Down | -0.0934069205 |
| PubMed_21979375_A1 | Down | -0.3934430130 |
| PubMed_21979375_A2 | Down | -0.0856936450 |
| GSE35957 | Down | -0.4580261622 |
| GSE36640 | Down | -0.1596531736 |
| GSE54402 | Down | -0.4995631973 |
| GSE9593 | Up | 0.0104969955 |
| GSE43922 | Up | 0.3638502595 |
| GSE24585 | Up | 0.4574453348 |
| GSE37065 | Up | 0.2118453958 |
| GSE28863_A1 | Down | -0.1158141576 |
| GSE28863_A2 | Up | 0.6280904350 |
| GSE28863_A3 | Down | -0.7251148714 |
| GSE28863_A4 | Down | -0.1506688669 |
| GSE48662 | Down | -0.0773550422 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017614 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019639 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-375 | MIMAT0000728 | MIRT019874 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT024182 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048455 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22178194 | Affymetrix gene array data showed NeuT-induced alterations in the transcription of many enzymes involved in lipid metabolism, several of which (ACSL3, CHPT1, PLD1, LIPG, MGLL, LDL and NPC1) could be confirmed by quantitative realtime PCR |
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