HCSGD entry for FGF1

1. General information

Official gene symbolFGF1
Entrez ID2246
Gene full namefibroblast growth factor 1 (acidic)
Other gene symbolsAFGF ECGF ECGF-beta ECGFA ECGFB FGF-1 FGF-alpha FGFA GLIO703 HBGF-1 HBGF1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001759Organ inductionIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIEAbiological_process
GO:0005104Fibroblast growth factor receptor bindingIEA IPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIDA IEA TAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIDA IEAcellular_component
GO:0005730NucleolusIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0007165Signal transductionNASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0008083Growth factor activityIDA IEAmolecular_function
GO:0008201Heparin bindingIDAmolecular_function
GO:0008284Positive regulation of cell proliferationIGIbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayIDA IEA IGI IPI TASbiological_process
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0030544Hsp70 protein bindingIEAmolecular_function
GO:0034605Cellular response to heatIDAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0044548S100 protein bindingIPImolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045542Positive regulation of cholesterol biosynthetic processIDAbiological_process
GO:0045766Positive regulation of angiogenesisIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIEAbiological_process
GO:0051781Positive regulation of cell divisionIDAbiological_process
GO:0060681Branch elongation involved in ureteric bud branchingIDAbiological_process
GO:0072163Mesonephric epithelium developmentIDAbiological_process
GO:1902533Positive regulation of intracellular signal transductionIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.84792377950.00151608220.99999024730.0756859848

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.2535329452
GSE13712_SHEARUp0.0098213684
GSE13712_STATICDown-0.0061012218
GSE19018Up0.1654973222
GSE19899_A1Down-0.4747749529
GSE19899_A2Down-2.2075519647
PubMed_21979375_A1Down-3.7336386127
PubMed_21979375_A2Down-2.2816201987
GSE35957Down-0.3849416826
GSE36640Up0.3433825464
GSE54402Down-1.5092147460
GSE9593Up0.4927745515
GSE43922Down-1.1838519724
GSE24585Up0.0547778395
GSE37065Down-0.1062735137
GSE28863_A1Down-0.5909201446
GSE28863_A2Down-0.0264743554
GSE28863_A3Up0.1055216087
GSE28863_A4Up0.1352567289
GSE48662Down-0.2029678033

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL382044CHEMBL21209P05230
CHEMBL198643CHEMBL21209P05230
CHEMBL265885CHEMBL21209P05230
CHEMBL308715CHEMBL21209P05230
CHEMBL430983CHEMBL21209P05230
CHEMBL1627092CHEMBL21208P05230
CHEMBL1627091CHEMBL21208P05230
CHEMBL258321CHEMBL21208P05230
CHEMBL1627090CHEMBL21208P05230
CHEMBL1160109CHEMBL21206P05230
CHEMBL1160110CHEMBL21206P05230
CHEMBL1160109CHEMBL21206P05230
CHEMBL1160113CHEMBL21206P05230
CHEMBL1160103CHEMBL21206P05230
CHEMBL1160108CHEMBL21206P05230
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  • Drugs

Name

Drug

Accession number

Pentosan PolysulfateDB00686 APRD01175
AmlexanoxDB01025 APRD00795
SucrosofateDB01901 EXPT02871
Formic AcidDB01942 EXPT01461
O2-Sulfo-Glucuronic AcidDB02264 EXPT01843
N,O6-Disulfo-GlucosamineDB03959 EXPT02898
Naphthalene TrisulfonateDB04409 EXPT02393
PazopanibDB06589 -
5-AMINO-NAPHTALENE-2-MONOSULFONATEDB08238 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022188MicroarrayFunctional MTI (Weak)18668037
hsa-miR-7-5pMIMAT0000252MIRT025666MicroarrayFunctional MTI (Weak)17612493
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21456046The expression of both genes was inversely correlated during senescence in vitro but contrary to the expectations in adipose tissue derived stem cells (ADSCs) stimulation of HMGA2 by FGF1 increased the expression of p14(Arf)
8972724Histone (H)3 mRNA was induced by serum in young cells, but not in senescent cells, and FGF-1 failed to induce H3 mRNA in either young or senescent cells
8972724Further, while young IMR-90 populations were able to respond to serum as an initiator of DNA synthesis and cell growth, they did not exhibit a response to exogenous FGF-1
8972724These data demonstrate that IL-1 alpha and FGF-1 may have different functions in HUVEC and IMR-90 fibroblast populations including distinct pathways for the regulation of cellular growth and senescence
8707855We report that in both presenescent and senescent HUVEC populations, FGF-1 induces the expression of cell cycle-specific genes, suggesting that functional FGF receptor (FGFR) may exist on the surface of these cells
8707855Moreover, we demonstrate that senescent HUVEC are unable to migrate in response to FGF-1, and these data correlate with an altered organization of focal adhesion sites
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