HCSGD entry for NLRP1

1. General information

Official gene symbolNLRP1
Entrez ID22861
Gene full nameNLR family, pyrin domain containing 1
Other gene symbolsCARD7 CIDED CLR17.1 DEFCAP DEFCAP-L/S NAC NALP1 PP1044 SLEV1 VAMAS1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005622IntracellularICcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006915Apoptotic processNASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDA NASbiological_process
GO:0006952Defense responseIEAbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0008656Cysteine-type endopeptidase activator activity involved in apoptotic processNASmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0032495Response to muramyl dipeptideISSbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0042742Defense response to bacteriumIEA ISSbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0050718Positive regulation of interleukin-1 beta secretionISSbiological_process
GO:0050727Regulation of inflammatory responseICbiological_process
GO:0051402Neuron apoptotic processIDAbiological_process
GO:0072558NLRP1 inflammasome complexIDA TAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95260279240.35891508300.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0794731191
GSE13712_SHEARDown-0.1070018547
GSE13712_STATICDown-0.2700730276
GSE19018Up0.0774600926
GSE19899_A1Up0.1290165312
GSE19899_A2Up0.0271761936
PubMed_21979375_A1Up0.0734006773
PubMed_21979375_A2Down-0.0573289760
GSE35957Down-0.1458325806
GSE36640Down-0.1036806066
GSE54402Down-0.1080345248
GSE9593Up0.0154602829
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.2881623000

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017810MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.