HCSGD entry for FLG


1. General information

Official gene symbolFLG
Entrez ID2312
Gene full namefilaggrin
Other gene symbolsATOD2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005198Structural molecule activityNASmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005882Intermediate filamentNAScellular_component
GO:0007275Multicellular organismal developmentNASbiological_process
GO:0016023Cytoplasmic membrane-bounded vesicleIDAcellular_component
GO:0030216Keratinocyte differentiationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05037197290.59331861630.49141612311.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0741200693
GSE13712_SHEARUp0.0786068867
GSE13712_STATICUp0.1114809317
GSE19018Up0.0907173578
GSE19899_A1Up0.0459920658
GSE19899_A2Up0.0688915545
PubMed_21979375_A1Down-0.0076048114
PubMed_21979375_A2Down-0.0525322182
GSE35957Up3.3888039111
GSE36640Down-0.0201712125
GSE54402Up0.1305067222
GSE9593Down-0.0368686285
GSE43922Up0.1512082752
GSE24585Up0.1080141855
GSE37065Down-0.7797885434
GSE28863_A1Down-0.1987868365
GSE28863_A2Up0.2130206281
GSE28863_A3Up0.0397638034
GSE28863_A4Down-0.0074100120
GSE48662Up0.9900612810

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022464MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26731545TE increased collagen-I, involucrin and filaggrin synthesis by 70
26731545TE increased the mRNA expression of collagen-I, elastin, superoxide dismutase (SOD-2), aquaporin-3 (AQP-3), filaggrin, involucrin, transglutaminase in HDF or HaCaT cells, and decreased the mRNA levels of tyrosinase in B16F10 cells
25840344Epidermal differentiation markers loricrin, filaggrin, involucrin and transglutaminase, also strongly decreased
21289643Consistently, coexpression of JunB and Ras induced premature epidermal differentiation concomitant with upregulation of p16 and filaggrin and downregulation of cyclin D1 and cyclin-dependent kinase 4 (CDK4)
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