HCSGD entry for PSME4
1. General information
| Official gene symbol | PSME4 |
|---|---|
| Entrez ID | 23198 |
| Gene full name | proteasome (prosome, macropain) activator subunit 4 |
| Other gene symbols | PA200 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0002474 | Antigen processing and presentation of peptide antigen via MHC class I | TAS | biological_process |
| GO:0002479 | Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | biological_process |
| GO:0005634 | Nucleus | ISS | cellular_component |
| GO:0005829 | Cytosol | ISS TAS | cellular_component |
| GO:0006281 | DNA repair | ISS | biological_process |
| GO:0006521 | Regulation of cellular amino acid metabolic process | TAS | biological_process |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | ISS | biological_process |
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010499 | Proteasomal ubiquitin-independent protein catabolic process | ISS | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0016504 | Peptidase activator activity | ISS | molecular_function |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0031145 | Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | TAS | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0035093 | Spermatogenesis, exchange of chromosomal proteins | ISS | biological_process |
| GO:0042590 | Antigen processing and presentation of exogenous peptide antigen via MHC class I | TAS | biological_process |
| GO:0042981 | Regulation of apoptotic process | TAS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0051437 | Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
| GO:0051439 | Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
| GO:0070577 | Histone acetyl-lysine binding | ISS | molecular_function |
| GO:1990111 | Spermatoproteasome complex | ISS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0557519509 | 0.3359978344 | 0.5143788165 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0698185973 |
| GSE13712_SHEAR | Up | 0.5468431068 |
| GSE13712_STATIC | Up | 0.4378865871 |
| GSE19018 | Down | -0.5175639612 |
| GSE19899_A1 | Up | 0.4201893902 |
| GSE19899_A2 | Up | 0.2785578354 |
| PubMed_21979375_A1 | Up | 0.3352306210 |
| PubMed_21979375_A2 | Up | 0.4434645387 |
| GSE35957 | Down | -0.1361475579 |
| GSE36640 | Up | 0.0683648302 |
| GSE54402 | Up | 0.5297387573 |
| GSE9593 | Up | 0.0044828433 |
| GSE43922 | Up | 0.2936278910 |
| GSE24585 | Down | -0.6024037271 |
| GSE37065 | Down | -0.0499089422 |
| GSE28863_A1 | Up | 0.1987607617 |
| GSE28863_A2 | Up | 0.9052377962 |
| GSE28863_A3 | Down | -0.5713562309 |
| GSE28863_A4 | Down | -0.2916324700 |
| GSE48662 | Down | -0.3243648917 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019934 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020902 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027763 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028604 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031835 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1303 | MIMAT0005891 | MIRT035894 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051708 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
