HCSGD entry for SYNE2
1. General information
| Official gene symbol | SYNE2 |
|---|---|
| Entrez ID | 23224 |
| Gene full name | spectrin repeat containing, nuclear envelope 2 |
| Other gene symbols | EDMD5 NUA NUANCE Nesp2 Nesprin-2 SYNE-2 TROPH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005635 | Nuclear envelope | IDA IEA | cellular_component |
| GO:0005640 | Nuclear outer membrane | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005925 | Focal adhesion | IDA | cellular_component |
| GO:0006998 | Nuclear envelope organization | IEA | biological_process |
| GO:0007097 | Nuclear migration | IMP | biological_process |
| GO:0007163 | Establishment or maintenance of cell polarity | IEA | biological_process |
| GO:0010761 | Fibroblast migration | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016529 | Sarcoplasmic reticulum | IDA | cellular_component |
| GO:0030018 | Z disc | IDA IEA | cellular_component |
| GO:0030335 | Positive regulation of cell migration | IEA ISS | biological_process |
| GO:0031022 | Nuclear migration along microfilament | IEA ISS | biological_process |
| GO:0031258 | Lamellipodium membrane | IDA | cellular_component |
| GO:0031527 | Filopodium membrane | IDA | cellular_component |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0031981 | Nuclear lumen | IDA | cellular_component |
| GO:0033017 | Sarcoplasmic reticulum membrane | IEA | cellular_component |
| GO:0034504 | Protein localization to nucleus | IEA | biological_process |
| GO:0034993 | SUN-KASH complex | IDA | cellular_component |
| GO:0051642 | Centrosome localization | IEA IMP | biological_process |
| GO:0090286 | Cytoskeletal anchoring at nuclear membrane | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5999235553 | 0.0656100186 | 0.9999902473 | 0.4835959955 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0445779166 |
| GSE13712_SHEAR | Down | -0.2574552057 |
| GSE13712_STATIC | Down | -0.2188783473 |
| GSE19018 | Up | 0.1333896592 |
| GSE19899_A1 | Up | 0.0024085412 |
| GSE19899_A2 | Down | -0.4009306610 |
| PubMed_21979375_A1 | Down | -0.4764115269 |
| PubMed_21979375_A2 | Up | 0.0063747175 |
| GSE35957 | Down | -0.2401861361 |
| GSE36640 | Down | -2.1685587598 |
| GSE54402 | Down | -0.1756963054 |
| GSE9593 | Down | -0.0945707218 |
| GSE43922 | Down | -1.0786640758 |
| GSE24585 | Up | 0.6410124434 |
| GSE37065 | Down | -0.1530473719 |
| GSE28863_A1 | Up | 0.4695783899 |
| GSE28863_A2 | Up | 0.3842647606 |
| GSE28863_A3 | Down | -0.0148617798 |
| GSE28863_A4 | Up | 0.0815742780 |
| GSE48662 | Down | -0.1667526431 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT001498 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016274 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019254 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021366 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-1 | MIMAT0000416 | MIRT023596 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025264 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029118 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030732 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-484 | MIMAT0002174 | MIRT041646 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052060 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25744025 | We show both prelamin A accumulation and increased DNA damage occur concomitantly, before VSMC replicative senescence, and induce the localisation of ERK1/2 to promyelocytic leukaemia protein nuclear bodies (PML NBs) at the sites of DNA damage via nesprin-2 and lamin A interactions |
| 25744025 | Importantly, VSMCs treated with DNA damaging agents also displayed prelamin A accumulation and ERK compartmentalisation at PML NBs, suggesting that prelamin A and nesprin-2 are novel components of the DDR |
| 25744025 | In support of this, disruption of ERK compartmentalisation at PML NBs, by either depletion of nesprin-2 or lamins A/C, resulted in the loss of ATM from DNA lesions |
| 25744025 | However, ATM signalling and DNA repair remained intact after lamins A/C depletion, whereas nesprin-2 disruption ablated downstream Chk2 activation and induced genomic instability |
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