HCSGD entry for RUSC1
1. General information
| Official gene symbol | RUSC1 |
|---|---|
| Entrez ID | 23623 |
| Gene full name | RUN and SH3 domain containing 1 |
| Other gene symbols | NESCA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0003779 | Actin binding | ISS | molecular_function |
| GO:0005070 | SH3/SH2 adaptor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005769 | Early endosome | ISS | cellular_component |
| GO:0005794 | Golgi apparatus | ISS | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0009967 | Positive regulation of signal transduction | TAS | biological_process |
| GO:0014069 | Postsynaptic density | IEA | cellular_component |
| GO:0015630 | Microtubule cytoskeleton | ISS | cellular_component |
| GO:0016023 | Cytoplasmic membrane-bounded vesicle | IEA | cellular_component |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0031410 | Cytoplasmic vesicle | ISS | cellular_component |
| GO:0045211 | Postsynaptic membrane | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1744668934 | 0.6798979522 | 0.8197890575 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2351242968 |
| GSE13712_SHEAR | Down | -0.2998132223 |
| GSE13712_STATIC | Up | 0.1314519496 |
| GSE19018 | Up | 0.0285399996 |
| GSE19899_A1 | Down | -0.1762696704 |
| GSE19899_A2 | Up | 0.1672920137 |
| PubMed_21979375_A1 | Up | 1.5928148435 |
| PubMed_21979375_A2 | Up | 1.5778542638 |
| GSE35957 | Down | -0.5308587483 |
| GSE36640 | Down | -0.2428640123 |
| GSE54402 | Up | 0.0853506141 |
| GSE9593 | Down | -0.1557592805 |
| GSE43922 | Up | 0.0510524065 |
| GSE24585 | Up | 0.2329801176 |
| GSE37065 | Up | 0.0165545536 |
| GSE28863_A1 | Down | -0.1609229016 |
| GSE28863_A2 | Up | 0.1207078299 |
| GSE28863_A3 | Up | 0.0649189097 |
| GSE28863_A4 | Down | -0.0896316234 |
| GSE48662 | Up | 0.1377497737 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016602 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025953 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-425-5p | MIMAT0003393 | MIRT039308 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
