HCSGD entry for ALPL
1. General information
| Official gene symbol | ALPL |
|---|---|
| Entrez ID | 249 |
| Gene full name | alkaline phosphatase, liver/bone/kidney |
| Other gene symbols | AP-TNAP APTNAP HOPS TNAP TNSALP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001501 | Skeletal system development | TAS | biological_process |
| GO:0001958 | Endochondral ossification | IEA | biological_process |
| GO:0003006 | Developmental process involved in reproduction | IEA | biological_process |
| GO:0004035 | Alkaline phosphatase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016462 | Pyrophosphatase activity | IDA IEA | molecular_function |
| GO:0031012 | Extracellular matrix | IEA | cellular_component |
| GO:0031225 | Anchored component of membrane | IEA | cellular_component |
| GO:0032496 | Response to lipopolysaccharide | IEA | biological_process |
| GO:0033280 | Response to vitamin D | IEP | biological_process |
| GO:0046677 | Response to antibiotic | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051384 | Response to glucocorticoid | IEA | biological_process |
| GO:0065010 | Extracellular membrane-bounded organelle | IEA | cellular_component |
| GO:0071407 | Cellular response to organic cyclic compound | IEA | biological_process |
| GO:0071529 | Cementum mineralization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2948750047 | 0.3714552563 | 0.9941997951 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1024788780 |
| GSE13712_SHEAR | Up | 0.0936984923 |
| GSE13712_STATIC | Down | -0.0689269514 |
| GSE19018 | Down | -0.0528658221 |
| GSE19899_A1 | Down | -0.0394627188 |
| GSE19899_A2 | Down | -0.0144999915 |
| PubMed_21979375_A1 | Down | -0.0793328799 |
| PubMed_21979375_A2 | Up | 0.0413588732 |
| GSE35957 | Down | -0.2266179444 |
| GSE36640 | Down | -0.0113905076 |
| GSE54402 | Up | 0.0689402850 |
| GSE9593 | Down | -0.4616645724 |
| GSE43922 | Up | 0.0297834587 |
| GSE24585 | Up | 0.1844536007 |
| GSE37065 | Down | -1.3691879415 |
| GSE28863_A1 | Up | 0.1779286424 |
| GSE28863_A2 | Up | 0.7617167779 |
| GSE28863_A3 | Up | 0.2164074419 |
| GSE28863_A4 | Down | -0.0339770106 |
| GSE48662 | Up | 0.4315415683 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | MIRT007116 | Luciferase reporter assay | Functional MTI | 23472141 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21627568 | However, matrix mineralization and expression of alkaline phosphatase (Alpl) and osteocalcin (Bglap) mRNA after osteogenic induction increased with TDSC passaging |
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