HCSGD entry for GABPB1
1. General information
| Official gene symbol | GABPB1 |
|---|---|
| Entrez ID | 2553 |
| Gene full name | GA binding protein transcription factor, beta subunit 1 |
| Other gene symbols | BABPB2 E4TF1 E4TF1-47 E4TF1-53 E4TF1B GABPB GABPB2 NRF2B1 NRF2B2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0044212 | Transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9671464838 | 0.0367080240 | 0.9999902473 | 0.3613259328 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3511425090 |
| GSE13712_SHEAR | Up | 0.3113793433 |
| GSE13712_STATIC | Down | -0.3365541503 |
| GSE19018 | Down | -0.2767268618 |
| GSE19899_A1 | Down | -0.1656025533 |
| GSE19899_A2 | Down | -0.1244147428 |
| PubMed_21979375_A1 | Up | 0.8866554293 |
| PubMed_21979375_A2 | Down | -0.3350759085 |
| GSE35957 | Down | -0.5797499002 |
| GSE36640 | Down | -1.0482899634 |
| GSE54402 | Up | 0.1928948931 |
| GSE9593 | Down | -0.5743481802 |
| GSE43922 | Up | 0.0150282338 |
| GSE24585 | Down | -0.1573336487 |
| GSE37065 | Down | -0.0079202257 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.4076502600 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024412 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25970806 | We discuss the recent findings on SIRT7 and its binding proteins, NRF1 and GABPbeta1, in decision making between the choices of inducing cell aging and immortality |
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