HCSGD entry for PAN3
1. General information
| Official gene symbol | PAN3 |
|---|---|
| Entrez ID | 255967 |
| Gene full name | PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000184 | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | IEA | biological_process |
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | TAS | biological_process |
| GO:0000289 | Nuclear-transcribed mRNA poly(A) tail shortening | TAS | biological_process |
| GO:0000290 | Deadenylation-dependent decapping of nuclear-transcribed mRNA | IEA | biological_process |
| GO:0000932 | Cytoplasmic mRNA processing body | IEA | cellular_component |
| GO:0004535 | Poly(A)-specific ribonuclease activity | IDA | molecular_function |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006605 | Protein targeting | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010606 | Positive regulation of cytoplasmic mRNA processing body assembly | IEA | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0031251 | PAN complex | IDA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | IDA | biological_process |
| GO:0090501 | RNA phosphodiester bond hydrolysis | IDA | biological_process |
| GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9592614490 | 0.0515180122 | 0.9999902473 | 0.4267300314 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3593602693 |
| GSE13712_SHEAR | Down | -0.2223935503 |
| GSE13712_STATIC | Down | -0.5225698081 |
| GSE19018 | Up | 0.0389697764 |
| GSE19899_A1 | Down | -0.1476297004 |
| GSE19899_A2 | Down | -0.1834673994 |
| PubMed_21979375_A1 | Up | 0.1392773833 |
| PubMed_21979375_A2 | Down | -0.2418670799 |
| GSE35957 | Down | -0.2531644511 |
| GSE36640 | Down | -0.5350280658 |
| GSE54402 | Up | 0.1649377606 |
| GSE9593 | Down | -0.3533897287 |
| GSE43922 | Down | -0.0895290010 |
| GSE24585 | Up | 0.0884969886 |
| GSE37065 | Up | 0.1116583239 |
| GSE28863_A1 | Up | 0.2937352050 |
| GSE28863_A2 | Down | -0.1414296987 |
| GSE28863_A3 | Down | -0.6161232635 |
| GSE28863_A4 | Up | 0.0379202954 |
| GSE48662 | Down | -0.0711473808 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148a-3p | MIMAT0000243 | MIRT025981 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030761 | Microarray | Functional MTI (Weak) | 18591254 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
